An important clue:: fingerprints point to psoriasin in defense against E-coli

被引:6
作者
Bevins, CL [1 ]
机构
[1] Univ Calif Davis, Sch Med, Dept Med Microbiol & Immunol, Davis, CA 95616 USA
关键词
D O I
10.1038/ni0105-12
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Human skin is surprisingly resistant to colonization by Escherichia coli, a prevalent commensal bacterium of the gut flora. An 11-kDa Zn2+-binding protein, psoriasin, is identified as the principal E. coli-bactericidal factor present at the surface of human skin.
引用
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页码:12 / 13
页数:3
相关论文
共 11 条
[1]   Antibacterial peptides: basic facts and emerging concepts [J].
Boman, HG .
JOURNAL OF INTERNAL MEDICINE, 2003, 254 (03) :197-215
[2]   S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles [J].
Donato, R .
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2001, 33 (07) :637-668
[3]   Defensins: Antimicrobial peptides of innate immunity [J].
Ganz, T .
NATURE REVIEWS IMMUNOLOGY, 2003, 3 (09) :710-720
[4]   Antimicrobial psoriasin (S100A7) protects human skin from Escherichia coli infection [J].
Gläser, R ;
Harder, J ;
Lange, H ;
Bartels, J ;
Christophers, E ;
Schröder, JM .
NATURE IMMUNOLOGY, 2005, 6 (01) :57-64
[5]  
LEHRER RI, MUCOSAL IMMUNOLOGY
[6]   MOLECULAR-CLONING, OCCURRENCE, AND EXPRESSION OF A NOVEL PARTIALLY SECRETED PROTEIN PSORIASIN THAT IS HIGHLY UP-REGULATED IN PSORIATIC SKIN [J].
MADSEN, P ;
RASMUSSEN, HH ;
LEFFERS, H ;
HONORE, B ;
DEJGAARD, K ;
OLSEN, E ;
KIIL, J ;
WALBUM, E ;
ANDERSEN, AH ;
BASSE, B ;
LAURIDSEN, JB ;
RATZ, GP ;
CELIS, A ;
VANDEKERCKHOVE, J ;
CELIS, JE .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1991, 97 (04) :701-712
[7]   Innate antimicrobial peptide protects the skin from invasive bacterial infection [J].
Nizet, V ;
Ohtake, T ;
Lauth, X ;
Trowbridge, J ;
Rudisill, J ;
Dorschner, RA ;
Pestonjamasp, V ;
Piraino, J ;
Huttner, K ;
Gallo, RL .
NATURE, 2001, 414 (6862) :454-457
[8]   Endogenous antimicrobial peptides and skin infections in atopic dermatitis [J].
Ong, PY ;
Ohtake, T ;
Brandt, C ;
Strickland, I ;
Boguniewicz, M ;
Ganz, T ;
Gallo, RL ;
Leung, DYM .
NEW ENGLAND JOURNAL OF MEDICINE, 2002, 347 (15) :1151-1160
[9]   Cathelicidins, multifunctional peptides of the innate immunity [J].
Zanetti, M .
JOURNAL OF LEUKOCYTE BIOLOGY, 2004, 75 (01) :39-48