Myc goes global: New tricks for an old oncogene

被引：104

作者：

Knoepfler, Paul S. ^{[1
]}

机构：

[1] Univ Calif Davis, Sch Med, Shriners Hosp Children, Inst Pediat Regenerat Med,Dept Cell Biol & Human, Davis, CA 95616 USA

来源：

CANCER RESEARCH | 2007年 / 67卷 / 11期

关键词：

D O I：

10.1158/0008-5472.CAN-07-0426

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Myc, a transcription factor commonly deregulated in tumorigenesis, is thought to mediate its diverse cellular effects by altering the expression of specific target genes. However, it has been difficult to gain a precise understanding of how Myc drives cancer because Myc acts rather weakly at many of its target loci, and it has been reported to regulate as many as 10% to 15% of all cellular genes. A new perspective on this issue has been provided by a recent study that revealed Myc can regulate chromatin structure in a global fashion. These findings suggest actions for Myc that extend beyond the traditional concept of a targeted gene regulator.

引用

页码：5061 / 5063

页数：3

共 25 条

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