The distribution of loss in two-treatment biased-coin designs

被引：13

作者：

Atkinson, AC ^{[1
]}

机构：

[1] London Sch Econ, London WC2A 2AE, England

来源：

BIOSTATISTICS | 2003年 / 4卷 / 02期

关键词：

balance; Bayesian coin; bias; biased-coin design; chi-squared approximation; D-A-optimum design; loss; minimization; randomization;

D O I：

10.1093/biostatistics/4.2.179

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The paper compares randomized rules of the biased-coin type for the sequential allocation of treatments in a clinical trial. An important characteristic is the loss, which measures the increase in the variance of parameter estimates due to the imbalance caused by randomization. Simulations are used to find the small-sample distribution of loss. For some rules a simple chi-squared approximation to the asymptotic distribution holds well down to very small sample sizes.

引用

页码：179 / 193

页数：15

共 23 条

[1] OPTIMUM BIASED COIN DESIGNS FOR SEQUENTIAL CLINICAL-TRIALS WITH PROGNOSTIC FACTORS [J].