Expression of ExsA in trans confers type III secretion system-dependent cytotoxicity on noncytotoxic Pseudomonas aeruginosa cystic fibrosis isolates

被引：61

作者：

Dacheux, D ^{[1
]}

Attree, I ^{[1
]}

Toussaint, B ^{[1
]}

机构：

[1] CEA Grenoble, DBMS, BBSI, UMR 5092,CNRS, F-38054 Grenoble 09, France

来源：

INFECTION AND IMMUNITY | 2001年 / 69卷 / 01期

关键词：

D O I：

10.1128/IAI.69.1.538-542.2001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Twelve Pseudomonas aeruginosa cystic fibrosis isolates that are not able to exert a type III secretion system (TTSS)-dependent cytotoxicity towards phagocytes have been further studied. The strains, although possessing TTSS genes and exsA, which encodes a positive regulator of the TTSS regulon, showed no transcriptional activation of the exsCBA regulatory operon. The expression of exsA in trans restored the in vitro secretion of TTSS proteins and ex vivo cytotoxicity.

引用

页码：538 / 542

页数：5

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