An antioxidant system required for host protection against gut infection in Drosophila

被引:288
作者
Ha, EM
Oh, CT
Ryu, JH
Bae, YS
Kang, SW
Jang, IH
Brey, PT
Lee, WJ [1 ]
机构
[1] Ewha Womans Univ, Div Mol Life Sci, Seoul 120750, South Korea
[2] Ewha Womans Univ, Ctr Cell Signaling Res, Seoul 120750, South Korea
[3] Inst Pasteur, Unite Biochim & Biol Mol Insectes, F-75724 Paris 15, France
关键词
D O I
10.1016/j.devcel.2004.11.007
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
A fundamental question that applies to all organisms is how barrier epithelia efficiently manage continuous contact with microorganisms. Here, we show that in Drosophila an extracellular immune-regulated catalase (IRC) mediates a key host defense system that is needed during host-microbe interaction in the gastrointestinal tract. Strikingly, adult flies with severely reduced IRC expression show high mortality rates even after simple ingestion of microbe-contaminated foods. However, despite the central role that the NF-kappaB pathway plays in eliciting antimicrobial responses, NF-kappaB pathway mutant flies are totally resistant to such infections. These results imply that homeostasis of redox balance by IRC is one of the most critical factors affecting host survival during continuous host-microbe interaction in the gastrointestinal tract.
引用
收藏
页码:125 / 132
页数:8
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