A fundamental question that applies to all organisms is how barrier epithelia efficiently manage continuous contact with microorganisms. Here, we show that in Drosophila an extracellular immune-regulated catalase (IRC) mediates a key host defense system that is needed during host-microbe interaction in the gastrointestinal tract. Strikingly, adult flies with severely reduced IRC expression show high mortality rates even after simple ingestion of microbe-contaminated foods. However, despite the central role that the NF-kappaB pathway plays in eliciting antimicrobial responses, NF-kappaB pathway mutant flies are totally resistant to such infections. These results imply that homeostasis of redox balance by IRC is one of the most critical factors affecting host survival during continuous host-microbe interaction in the gastrointestinal tract.
机构:
Mem Sloan Kettering Canc Ctr, Sloan Kettering Inst, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Sloan Kettering Inst, New York, NY 10021 USA
Brennan, CA
;
Anderson, KV
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机构:
Mem Sloan Kettering Canc Ctr, Sloan Kettering Inst, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Sloan Kettering Inst, New York, NY 10021 USA
机构:
Mem Sloan Kettering Canc Ctr, Sloan Kettering Inst, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Sloan Kettering Inst, New York, NY 10021 USA
Brennan, CA
;
Anderson, KV
论文数: 0引用数: 0
h-index: 0
机构:
Mem Sloan Kettering Canc Ctr, Sloan Kettering Inst, New York, NY 10021 USAMem Sloan Kettering Canc Ctr, Sloan Kettering Inst, New York, NY 10021 USA