Electrooxidation of the antileukemic 2-chloro-2′-deoxyadenosine and related compounds

被引：8

作者：

Bojarska, E ^{[1
]}

Czochralska, B ^{[1
]}

机构：

[1] Univ Warsaw, Inst Expt Phys, Dept Biophys, PL-02089 Warsaw, Poland

来源：

JOURNAL OF ELECTROANALYTICAL CHEMISTRY | 1999年 / 477卷 / 01期

关键词：

2-chloro-2 '-deoxyadenosine; cladribine; antileukemic agents; voltammetric analysis; electrochemical oxidation mechanism; xanthine oxidase; HPLC analysis;

D O I：

10.1016/S0022-0728(99)00394-0

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The electrochemical oxidation process of 2-halogenoderivatives: 2-chloro-2'-deoxy- adenosine (2CldAdo), 2-bromo-2'-deoxyadenosine (2BrdAdo) and 2'-deoxyadenosine (2'dAdo) has been studied in aqueous buffered solutions by DPV and CV using a glassy-carbon electrode. All compounds investigated exhibit one-step electrochemical oxidation in the pH range 2-9. Macroelectrolyses at the potential corresponding to DPV oxidation peaks have been performed in acetate buffer (pH 4.5) using a pyrolytic graphite electrode. While oxidation of 2BrdAdo occurred with elimination of Br-2, no liberation of Cl atom was found for oxidation of 2CldAdo. The oxidation products of the compounds investigated have been examined by UV spectroscopy, electrochemical and HPLC analysis. The mechanism of electrochemical oxidation of halogenated deoxyadenosines is proposed. (C) 1999 Elsevier Science S.A. All rights reserved.

引用

页码：89 / 96

页数：8

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