The APP family of proteins: similarities and differences

被引：109

作者：

Walsh, D. M. ^{[1
]}

Minogue, A. M.

Frigerio, C. Sala

Fadeeva, J. V.

Wasco, W.

Selkoe, D. J.

机构：

[1] Univ Coll Dublin, Conway Inst, Lab Neurodegenerat Res, Dublin 2, Ireland

[2] Brigham & Womens Hosp, Ctr Neurol Dis, Boston, MA 02115 USA

[3] Harvard Univ, Sch Med, Dept Neurol, Boston, MA 02115 USA

[4] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Genet & Aging Res Unit, Boston, MA 02129 USA

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2007年 / 35卷

基金：

英国惠康基金;

关键词：

Alzheimer's disease; beta-amyloid-cleaving enzyme (BACE); amyloid precursor protein (APP); amyloid precursor-like protein (APLP); gamma-secretase; therapy;

D O I：

10.1042/BST0350416

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

overwhelming evidence indicates that the A beta (amyloid beta-peptide) plays a critical role in the pathogenesis of Alzheimer's disease. A beta is derived from the APP (amyloid precursor protein) by the action of two aspartyl proteases (beta- and gamma-secretases) that are leading candidates for therapeutic intervention. APP is a member of a multigene family that includes APLP1 (amyloid precursor-like protein 1) and APLP2. Both APLPs are processed in a manner analogous to APP, with all three proteins subject to ectodomain shedding and subsequent cleavage by gamma-secretase. Careful study of the APP family of proteins has already revealed important insights about APP. Here, we will review how knowledge of the similarities and differences between APP and the APLPs may prove useful for the development of novel disease-modifying therapeutics.

引用

页码：416 / 420

页数：5

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