Signalling pathways underlying neural cell adhesion molecule-mediated survival of dopaminergic neurons

被引：32

作者：

Ditlevsen, Dorte Kornerup

Berezin, Vladimir

Bock, Elisabeth

机构：

[1] Univ Copenhagen, Prot Lab, Dept Neurosci & Pharmacol, Panum Inst, DK-2200 Copenhagen, Denmark

[2] Enkam Pharmaceut AS, DK-2100 Copenhagen, Denmark

来源：

EUROPEAN JOURNAL OF NEUROSCIENCE | 2007年 / 25卷 / 06期

关键词：

CaMK; differentiation; neuroprotection; PLC; rat;

D O I：

10.1111/j.1460-9568.2007.05436.x

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Stimulation of the neural cell adhesion molecule (NCAM) by homophilic interactions is known to lead to neurite outgrowth as well as to neuronal survival. Whereas a complex network of signalling molecules is known to be of importance to NCAM-mediated neurite extension, only limited information is available regarding signalling underlying NCAM-mediated neuroprotection. Here, we present data suggesting a difference in the signalling events required for survival of rat dopaminergic neurons as compared with neurite outgrowth from the same cell type. Whereas Fyn, fibroblast growth factor receptor, mitogen-activated protein and ERK kinase, protein kinase A and protein kinase C are required for both responses to NCAM-induced signalling, phospholipase C and Ca2+-calmodulin-dependent kinase II are only necessary for the neurite outgrowth response, but dispensable for neuroprotection.

引用

页码：1678 / 1684

页数：7

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