The First-Generation Drug-Eluting Stents and Coronary Endothelial Dysfunction

被引：87

作者：

Pendyala, Lakshmana K. ^{[1
]}

Yin, Xinhua ^{[2
]}

Li, Jinsheng ^{[2
]}

Chen, Jack P. ^{[2
]}

Chronos, Nicolas ^{[2
]}

Hou, Dongming ^{[2
]}

机构：

[1] Univ Louisville, Dept Cardiol, Louisville, KY 40292 USA

[2] St Josephs Hosp, St Josephs Res Inst, Atlanta, GA 30342 USA

来源：

JACC-CARDIOVASCULAR INTERVENTIONS | 2009年 / 2卷 / 12期

关键词：

drug-eluting stents; endothelial; vasomotor dysfunction; BARE-METAL STENTS; RANDOMIZED CLINICAL-TRIALS; ARTERIAL SMOOTH-MUSCLE; CELL PROLIFERATION; NITRIC-OXIDE; VASCULAR DYSFUNCTION; VASOMOTOR FUNCTION; VASA VASORUM; SIROLIMUS; IMPLANTATION;

D O I：

10.1016/j.jcin.2009.10.004

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Recently, a growing body of clinical data has shown that the first generation of drug-eluting stents (1st-gen DES) implantation could elicit coronary conduit artery vasomotor dysfunction at nonstented reference segments as late as 12 months after implantation compared with that seen with bare-metal stents. The mechanism of this phenomenon is still not fully understood. Pathological studies have implicated delayed arterial healing and poor re-endothelialization after the 1st-gen DES implantation. Given the vast use of DES globally, a thorough understanding of the early and long-term safety of these devices is paramount. Therefore, this article systematically reviews the current clinical, pathophysiological, and histopathological available data regarding 1st-gen DES-associated vascular endothelial dysfunction. Meanwhile, we will also review the newer generation of DES and emerging endothelial-friendly technology. (J Am Coll Cardiol Intv 2009;2:1169-77) (C) 2009 by the American College of Cardiology Foundation

引用

页码：1169 / 1177

页数：9

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