Feasibility of 18F-Sodium Fluoride PET/CT for Imaging of Atherosclerotic Plaque

被引：218

作者：

Derlin, Thorsten ^{[1
]}

Richter, Ulrich ^{[2
]}

Bannas, Peter ^{[3
]}

Begemann, Philipp ^{[3
]}

Buchert, Ralph ^{[4
]}

Mester, Janos ^{[1
]}

Klutmann, Susanne ^{[1
]}

机构：

[1] Univ Med Ctr Hamburg Eppendorf, Dept Nucl Med, D-20246 Hamburg, Germany

[2] Univ Med Ctr Hamburg Eppendorf, Dept Anat Expt Morphol 2, D-20246 Hamburg, Germany

[3] Univ Med Ctr Hamburg Eppendorf, Dept Diagnost & Intervent Radiol, D-20246 Hamburg, Germany

[4] Charite, Dept Nucl Med, Berlin, Germany

来源：

JOURNAL OF NUCLEAR MEDICINE | 2010年 / 51卷 / 06期

关键词：

F-18-sodium fluoride; plaque; atherosclerosis; calcification; PET; PET/CT; POSITRON-EMISSION-TOMOGRAPHY; MATRIX GLA PROTEIN; VASCULAR CALCIFICATION; F-18-FDG PET/CT; INFLAMMATION; EXPRESSION; ARTERIES; BIOLOGY; LESIONS; MICE;

D O I：

10.2967/jnumed.110.076471

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

The aim of this study was to examine the prevalence, distribution, and topographic relationship of vascular F-18-sodium fluoride uptake and arterial calcification in major arteries. Methods: Image data obtained from 75 patients undergoing whole-body F-18-sodium fluoride PET/CT were evaluated retrospectively. Arterial radiotracer uptake and calcification were analyzed qualitatively and semiquantitatively. Results: F-18-sodium fluoride uptake was observed at 254 sites in 57 (76%) of the 75 study patients, and calcification was observed at 1,930 sites in 63 (84%) of the patients. Colocalization of radiotracer accumulation and calcification could be observed in 223 areas of uptake (88%). However, only 12% of all arterial calcification sites showed increased radiotracer uptake. Conclusion: Our data indicate the feasibility of F-18-sodium fluoride PET/CT for the imaging of mineral deposition in arterial wall alterations. F-18-sodium fluoride PET/CT may provide relevant information about the morphologic and functional properties of calcified plaque.

引用

页码：862 / 865

页数：4

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