Ochratoxin A acts as a photoactivatable DNA cleaving agent

被引：27

作者：

Gillman, IG ^{[1
]}

Yezek, JM ^{[1
]}

Manderville, RA ^{[1
]}

机构：

[1] Wake Forest Univ, Dept Chem, Winston Salem, NC 27109 USA

来源：

CHEMICAL COMMUNICATIONS | 1998年 / 06期

关键词：

D O I：

10.1039/a708275d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The ability of ochratoxin A to photoinduce DNA cleavage is described; in the presence of DNA the photoreaction yields the non-chlorinated derivative, ochratoxin B, while a hydroquinone derivative is produced under anaerobic conditions.

引用

页码：647 / 648

页数：2

共 23 条

[1] ARDUS JA, IN PRESS CAN J CHEM
[2] METALS AND DNA - MOLECULAR LEFT-HANDED COMPLEMENTS
BARTON, JK
[J]. SCIENCE, 1986, 233 (4765) : 727 - 734
[3] EFFECT OF SUPEROXIDE-DISMUTASE AND CATALASE ON THE NEPHROTOXICITY INDUCED BY SUBCHRONICAL ADMINISTRATION OF OCHRATOXIN-A IN RATS
BAUDRIMONT, I
BETBEDER, AM
GHARBI, A
PFOHLLESZKOWICZ, A
DIRHEIMER, G
CREPPY, EE
[J]. TOXICOLOGY, 1994, 89 (02) : 101 - 111
[4] BUCHI G, 1982, J AM CHEM SOC, V104, P544, DOI 10.1021/ja00366a029
[5] AROMATIC-SUBSTITUTION BY SRN1 MECHANISM
BUNNETT, JF
[J]. ACCOUNTS OF CHEMICAL RESEARCH, 1978, 11 (11) : 413 - 420
[6] DAVIDOUDJEHANI K, 1995, NEW J CHEM, V19, P199
[7] FORMATION OF OCHRATOXIN-A METABOLITES AND DNA-ADDUCTS IN MONKEY KIDNEY-CELLS
GROSSE, Y
BAUDRIMONT, I
CASTEGNARO, M
BETBEDER, AM
CREPPY, EE
DIRHEIMER, G
PFOHLLESZKOWICZ, A
[J]. CHEMICO-BIOLOGICAL INTERACTIONS, 1995, 95 (1-2) : 175 - 187
[8] NADPH-CYTOCHROME-P-450 REDUCTASE PROMOTED HYDROXYL RADICAL PRODUCTION BY THE IRON(III)-OCHRATOXIN-A COMPLEX
HASINOFF, BB
RAHIMTULA, AD
OMAR, RF
[J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1990, 1036 (01) : 78 - 81
[9] Induction of free radicals in hepatocytes, mitochondria and microsomes of rats by ochratoxin A and its analogs
Hoehler, D
Marquardt, RR
McIntosh, AR
Hatch, GM
[J]. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 1997, 1357 (02): : 225 - 233
[10] Free radical generation as induced by ochratoxin A and its analogs in bacteria (Bacillus brevis)
Hoehler, D
Marquardt, RR
McIntosh, AR
Xiao, H
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (44) : 27388 - 27394

← 1 2 3 →