Type IV collagen as an early marker for diabetic nephropathy in non-insulin-dependent diabetes mellitus

被引：53

作者：

Kotajima, N ^{[1
]}

Kimura, T ^{[1
]}

Kanda, T ^{[1
]}

Obata, K ^{[1
]}

Kuwabara, A ^{[1
]}

Fukumura, Y ^{[1
]}

Kobayashi, I ^{[1
]}

机构：

[1] Gunma Univ, Sch Med, Dept Lab Med, Maebashi, Gumma 3718511, Japan

来源：

JOURNAL OF DIABETES AND ITS COMPLICATIONS | 2000年 / 14卷 / 01期

关键词：

diabetic nephropathy; non-insulin-dependent diabetes mellitus; urinary albumin; urinary transferrin; urinary type IV collagen;

D O I：

10.1016/S1056-8727(00)00064-7

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We measured urinary albumin (U-Alb) and type IV collagen (uIV.C) in spot urine collected from 82 patients with non-insulin-dependent diabetes mellitus (NIDDM) and 205 controls. Eighty-two NIDDM patients that had no increased excretion of either U-Alb or uIV.C were observed for 6 months. Prevalence of increased excretion of U-Alb and uIV.C at 6 months in these patients were 32.9%, and 62.2%, respectively. Increased excretion of uIV.C was detected in 27 patients without microalbuminuria. chi(2) analysis suggested that uIV.C was more sensitive than U-Alb, and that hypertension enhanced increased excretion of both U-Alb and uIV.C. uIV.C was significantly correlated (P < 0.01) with U-Alb but not glycosylated hemoglobin A1C (HbA1C) in NIDDM patients. Taken together, uIV.C may be a useful marker for early diabetic nephropathy. (C) 2000 Elsevier Science Inc. All rights reserved.

引用

页码：13 / 17

页数：5

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