Diminished striatal [123I]iodobenzovesamicol binding in idiopathic cervical dystonia

被引：21

作者：

Albin, RL

Cross, D

Cornblath, WT

Wald, JA

Wernette, K

Frey, KA

Minoshima, S

机构：

[1] Univ Michigan, Ann Arbor VAMC, Ctr Geriatr Res Educ & Clin, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Dept Neurol, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Grad Program Neurosci, Ann Arbor, MI 48109 USA

[4] Univ Washington, Dept Radiol, Seattle, WA 98195 USA

[5] Univ Michigan, Dept Ophthalmol, Ann Arbor, MI USA

[6] Univ Michigan, Dept Radiol, Ann Arbor, MI 48109 USA

来源：

ANNALS OF NEUROLOGY | 2003年 / 53卷 / 04期

关键词：

D O I：

10.1002/ana.10527

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Striatal dysfunction is thought to underlie many dystonias. We used [I-123] iodobenzovesamicol single-photon emission computed tomography imaging to determine the density of cholinergic terminals in the striatum and other brain regions in 13 subjects with idiopathic cervical dystonia. Striatal [I-131] iodobenzovesamicol binding was reduced. These results support a role for striatal dysfunction in idiopathic dystonias and suggest diminished striatal cholinergic interneuron density in cervical dystonia.

引用

页码：528 / 532

页数：5

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