Characterization of V36C, a Novel Amino Acid Substitution Conferring Hepatitis C Virus (HCV) Resistance to Telaprevir, a Potent Peptidomimetic Inhibitor of HCV Protease

被引：11

作者：

Barbotte, Laetitia ^{[2
]}

Ahmed-Belkacem, Abdelhakim ^{[2
]}

Chevaliez, Stephane ^{[1
,2
]}

Soulier, Alexandre ^{[1
,2
]}

Hezode, Christophe ^{[2
,3
]}

Wajcman, Henri ^{[2
]}

Bartels, Doug J. ^{[4
]}

Zhou, Yi ^{[4
]}

Ardzinski, Andrzej ^{[4
]}

Mani, Nagraj ^{[4
]}

Rao, B. Govinda ^{[4
]}

George, Shelley ^{[4
]}

Kwong, Ann ^{[4
]}

Pawlotsky, Jean-Michel ^{[1
,2
]}

机构：

[1] Univ Paris 12, Dept Virol, Hop Henri Mondor, Natl Reference Ctr Viral Hepatitis B C & Delta, F-94010 Creteil, France

[2] Hop Henri Mondor, INSERM, U955, F-94010 Creteil, France

[3] Univ Paris 12, Dept Gastroenterol & Hepatol, Henri Mondor Hosp, F-94010 Creteil, France

[4] Vertex Pharmaceut Inc, Cambridge, MA USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2010年 / 54卷 / 06期

关键词：

PEGINTERFERON; INFECTION; RIBAVIRIN;

D O I：

10.1128/AAC.01796-09

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We characterized a novel substitution conferring moderate resistance to telaprevir, a peptidomimetic inhibitor of hepatitis C virus protease. V36C conferred a 4.0-fold increase in the telaprevir 50% inhibitory concentration in an enzyme assay and a 9.5-fold increase in the replicon model. The replication capacity of a replicon harboring V36C was close to that of the wild-type protease. This case emphasizes the complexity of hepatitis C virus resistance to protease inhibitors.

引用

页码：2681 / 2683

页数：3

共 7 条

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