Thyroid cell transformation inhibits the expression of a novel rat protein tyrosine phosphatase

被引：48

作者：

Zhang, L

Martelli, ML

Battaglia, C

Trapasso, F

Tramontano, R

Viglietto, G

Porcellini, A

Santoro, M

Fusco, A

机构：

[1] UNIV REGGIO CALABRIA,FAC MED & CHIRURG CATANZARO,DIPARTIMENTO MED SPERIMENTALE & CLIN,I-88100 CATANZARO,ITALY

[2] INST TUMORI NAPOLI,I-80131 NAPLES,ITALY

[3] UNIV NAPLES FEDERICO II,FAC MED & CHIRURG,DIPARTIMENTO BIOL & PATOL CELLULARE & MOL,CNR,I-80131 NAPLES,ITALY

来源：

EXPERIMENTAL CELL RESEARCH | 1997年 / 235卷 / 01期

关键词：

D O I：

10.1006/excr.1997.3659

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We have isolated a rat thyroid cDNA encoding a novel rat receptor-type tyrosine phosphatase protein. This gene, on the basis of its homology to another tyrosine phosphatase, the recently isolated human DEP-1/HPTP eta, has been named r-PTP eta. In rat thyroid cells the r-PTP eta gene acts as a differentiation marker, Indeed, the block of thyroid cell differentiation induced by viral and cellular oncogenes is associated with the inhibition or marked reduction of the expression of this gene and its expression is positively regulated by thyrotropin, the physiological stimulator of thyroid cell growth. (C) 1997 Academic Press.

引用

页码：62 / 70

页数：9

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