Synthesis and biological activity of n-butylphthalide derivatives

被引：59

作者：

Wang, Wei ^{[1
]}

Cha, Xue-Xiang ^{[2
]}

Reiner, John ^{[1
]}

Gao, Yuan ^{[2
]}

Qiao, Hai-Ling ^{[2
]}

Shen, Jia-Xiang ^{[1
]}

Chang, Jun-Biao ^{[1
,2
]}

机构：

[1] Tianjin Univ, Coll Pharmaceut Sci & Technol, Tianjin 300072, Peoples R China

[2] Zhengzhou Univ, Basic Med Coll, Dept Pharmacol, Zhengzhou 450001, Peoples R China

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2010年 / 45卷 / 05期

基金：

中国国家自然科学基金;

关键词：

Vasorelaxant effects; Synthesis; n-Butylphalide; FOCAL CEREBRAL-ISCHEMIA; BLOOD-FLOW; RATS; DL-3-N-BUTYLPHTHALIDE; BRAIN; MODEL; ACID;

D O I：

10.1016/j.ejmech.2010.01.036

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of n-butylphthalide derivatives were designed and synthesized. The in vitro activities of these compounds were evaluated by a resting tension of isolated rat thoracic aorta ring assay. Compounds 4g and 41 were found to be more active than n-butylphthalide. (C) 2010 Elsevier Masson SAS. All rights reserved.

引用

页码：1941 / 1946

页数：6

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