Structure elucidation and antioxidant activity of a novel α-(1 → 3),(1 → 4)-D-glucan from Aconitum kusnezoffii Reichb.

被引：31

作者：

Gao, Tingting ^{[1
]}

Bi, Hongtao ^{[1
]}

Ma, Shuai ^{[2
]}

Lu, Jingmei ^{[1
]}

机构：

[1] NE Normal Univ, Sch Life Sci, Changchun 130024, Jilin Province, Peoples R China

[2] China Med Univ, Affiliated Hosp 1, Dept Oncosurg, Shenyang 110001, Peoples R China

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2010年 / 46卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Aconitum kusnezoffii Reichb; Polysaccharide; Glucan; Structure; Antioxidant; LIPID-PEROXIDATION; ARROW POISONS; POLYSACCHARIDES; CHROMATOGRAPHY; MECHANISMS; INHIBITORS;

D O I：

10.1016/j.ijbiomac.2009.10.011

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Aconitum kusnezoffii Reichb. has been used as traditional Chinese medicine over the last 2500 years, but its polysaccharides have been paid little attention by now. In the present study, a hot alkali extracted polysaccharide (AKP) from A. kusnezoffii Reichb. was characterized to be an alpha-(1 -> 3),(1 -> 4)-D-glucan with Mw 1.4 x 10(5) Da, of which (1 -> 3)-linked and (1 -> 4)-linked alpha-Glcp residues were in a ratio of 1:7. In vitro antioxidant testing indicated that AKP had significant ferrous ion-chelating ability, reducing power and scavenging effects on DPPH radical, hydroxyl radical, superoxide anion, H2O2 and self-oxidation of 1,2,3-phentriol, suggesting that it should be explored as a novel natural antioxidant. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：85 / 90

页数：6

共 32 条

[1]

ARROW POISONS IN CHINA .2. ACONITUM-BOTANY, CHEMISTRY, AND PHARMACOLOGY [J].