Control of pre-T cell proliferation and differentiation by the GTPase Rac-I

被引:75
作者
Gomez, M
Tybulewicz, V
Cantrell, DA
机构
[1] Imperial Canc Res Fund, Lymphocyte Activat Lab, London WC2A 3PX, England
[2] Natl Inst Med Res, London NW7 1AA, England
基金
英国医学研究理事会;
关键词
D O I
10.1038/79808
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The GTPase Rac-1 has the potential for pleiotropic functions due to its ability to interact with multiple effecters, Here, activation of Rac-1 is shown to potently regulate pre-T cell differentiation and proliferation at the point of T cell antigen receptor (TCR) beta selection. An activated Rac-1 effector domain mutant that restricts signaling to particular actions on actin dynamics can drive prei cell differentiation. Rac-1 activation cannot fully substitute for the pre-TCR complex but can fully correct defects in pre-T cell development in mice lacking the adapter molecule Vav-1. The present study identifies the subset of Rac-1 responses that mediate Vav-1 action as critical regulators of TCR beta selection.
引用
收藏
页码:348 / 352
页数:5
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