Efficient general method for sulfamoylation of a hydroxyl group

被引：120

作者：

Okada, M ^{[1
]}

Iwashita, S ^{[1
]}

Koizumi, N ^{[1
]}

机构：

[1] Teikoku Hormone Mfg Co Ltd, Organ Chem Res Dept, Takatsu Ku, Kawasaki, Kanagawa 2138522, Japan

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 36期

关键词：

solvents and solvent effects; phenols; alcohols; sulfamoylation; sulfamic acid and derivatives;

D O I：

10.1016/S0040-4039(00)01130-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The application of N,N-dimethylacetamide or 1-methyl-2-pyrrolidone as solvent clearly accelerated the sulfamoylation reaction of a hydroxyl group compared with the solvents used so far. The target sulfamates were obtained in the highest yield without a base. It became clear that 2 equiv. of sulfamoyl chloride to the starting material was sufficient to complete the reaction. It was confirmed that this condition could be applied to extensive hydroxyl groups, (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：7047 / 7051

页数：5

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