Angiotensin-(1-7): A novel peptide in the ovary

被引：49

作者：

Costa, APR ^{[1
]}

Fagundes-Moura, CR ^{[1
]}

Pereira, VM ^{[1
]}

Silva, LF ^{[1
]}

Vieira, MAR ^{[1
]}

Santos, RAS ^{[1
]}

Dos Reis, AM ^{[1
]}

机构：

[1] Univ Fed Minas Gerais, Inst Biol Sci, Dept Physiol & Biophys, BR-31270901 Belo Horizonte, MG, Brazil

来源：

ENDOCRINOLOGY | 2003年 / 144卷 / 05期

关键词：

D O I：

10.1210/en.2002-220787

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The present study was undertaken to investigate the presence of angiotensin-(1-7) [Ang-(1-7)] in the ovary and a possible role for it. Cycling female rats were killed in each phase of the estrous cycle, and ovarian Ang II and Ang-(1-7) were separated by HPLC and measured by RIA. The mean levels of Ang-(1-7) in proestrus and estrus were significantly higher than those in metestrus and diestrus (P < 0.05). Ang-(1-7) was also significantly higher in equine chorionic gonadotropin (eCG)-treated immature rats. Ang-(1-7) induced a significant increase in estradiol and progesterone production (P < 0.05) in the ovary of immature rats (24-25 d old) pretreated with eCG and perfused in a closed circuit system. This effect was blocked by A-779, a specific Ang-(1-7) antagonist (P < 0.05). The present data demonstrate the presence and physiological role of a novel renin-Ang system peptide in the ovary. The higher level of Ang-(1-7) in proestrus and estrus as well as in eCG-treated rats suggests the involvement of this renin-Ang system peptide in pre- and postovulatory events.

引用

页码：1942 / 1948

页数：7

共 48 条

[1] ANGIOTENSIN-II RECEPTORS IN THE GONADS [J].