STRUCTURAL BIOLOGY The gatekeepers revealed

被引:15
作者
Baker, Monya
机构
[1] Monya Baker is technology editor of Nature and Nature Methods.,
关键词
PROTEIN-COUPLED RECEPTOR; CRYSTAL-STRUCTURE; RESOLUTION; MEMBRANE; RHODOPSIN;
D O I
10.1038/465823a
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Proteins in cell membranes are notoriously hard to crystallize, but new techniques give scientists the means to map them. Monya Baker scouts out the tools for cracking the structure of membrane proteins.
引用
收藏
页码:823 / 828
页数:6
相关论文
共 12 条
[1]   High-resolution crystal structure of an engineered human β2-adrenergic G protein-coupled receptor [J].
Cherezov, Vadim ;
Rosenbaum, Daniel M. ;
Hanson, Michael A. ;
Rasmussen, Soren G. F. ;
Thian, Foon Sun ;
Kobilka, Tong Sun ;
Choi, Hee-Jung ;
Kuhn, Peter ;
Weis, William I. ;
Kobilka, Brian K. ;
Stevens, Raymond C. .
SCIENCE, 2007, 318 (5854) :1258-1265
[2]   STRUCTURE OF THE PROTEIN SUBUNITS IN THE PHOTOSYNTHETIC REACTION CENTER OF RHODOPSEUDOMONAS-VIRIDIS AT 3A RESOLUTION [J].
DEISENHOFER, J ;
EPP, O ;
MIKI, K ;
HUBER, R ;
MICHEL, H .
NATURE, 1985, 318 (6047) :618-624
[3]   The 2.6 Angstrom Crystal Structure of a Human A2A Adenosine Receptor Bound to an Antagonist [J].
Jaakola, Veli-Pekka ;
Griffith, Mark T. ;
Hanson, Michael A. ;
Cherezov, Vadim ;
Chien, Ellen Y. T. ;
Lane, J. Robert ;
IJzerman, Adriaan P. ;
Stevens, Raymond C. .
SCIENCE, 2008, 322 (5905) :1211-1217
[4]   A limited universe of membrane protein families and folds [J].
Oberai, Amit ;
Ihm, Yungok ;
Kim, Sanguk ;
Bowie, James U. .
PROTEIN SCIENCE, 2006, 15 (07) :1723-1734
[5]   Structural imperatives impose diverse evolutionary constraints on helical membrane proteins [J].
Oberai, Amit ;
Joh, Nathan H. ;
Pettit, Frank K. ;
Bowie, James U. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (42) :17747-17750
[6]   Crystal structure of rhodopsin: A G protein-coupled receptor [J].
Palczewski, K ;
Kumasaka, T ;
Hori, T ;
Behnke, CA ;
Motoshima, H ;
Fox, BA ;
Le Trong, I ;
Teller, DC ;
Okada, T ;
Stenkamp, RE ;
Yamamoto, M ;
Miyano, M .
SCIENCE, 2000, 289 (5480) :739-745
[7]   Crystal structure of the human β2 adrenergic G-protein-coupled receptor [J].
Rasmussen, Soren G. F. ;
Choi, Hee-Jung ;
Rosenbaum, Daniel M. ;
Kobilka, Tong Sun ;
Thian, Foon Sun ;
Edwards, Patricia C. ;
Burghammer, Manfred ;
Ratnala, Venkata R. P. ;
Sanishvili, Ruslan ;
Fischetti, Robert F. ;
Schertler, Gebhard F. X. ;
Weis, William I. ;
Kobilka, Brian K. .
NATURE, 2007, 450 (7168) :383-U4
[8]   GPCR engineering yields high-resolution structural insights into β2-adrenergic receptor function [J].
Rosenbaum, Daniel M. ;
Cherezov, Vadim ;
Hanson, Michael A. ;
Rasmussen, Soren G. F. ;
Thian, Foon Sun ;
Kobilka, Tong Sun ;
Choi, Hee-Jung ;
Yao, Xiao-Jie ;
Weis, William I. ;
Stevens, Raymond C. ;
Kobilka, Brian K. .
SCIENCE, 2007, 318 (5854) :1266-1273
[9]   PROJECTION STRUCTURE OF RHODOPSIN [J].
SCHERTLER, GFX ;
VILLA, C ;
HENDERSON, R .
NATURE, 1993, 362 (6422) :770-772
[10]   Super-resolution biomolecular crystallography with low-resolution data [J].
Schroeder, Gunnar F. ;
Levitt, Michael ;
Brunger, Axel T. .
NATURE, 2010, 464 (7292) :1218-U146