Exosomes in Intestinal Inflammation

被引：44

作者：

Ayyar, Kanchana K. ^{[1
]}

Moss, Alan C. ^{[1
]}

机构：

[1] Boston Med Ctr, Dept Med, Div Gastroenterol, Boston, MA 02118 USA

来源：

FRONTIERS IN PHARMACOLOGY | 2021年 / 12卷

关键词：

IBD; colitis; extracellular vesicles; exosomes; inflammation; OUTER-MEMBRANE VESICLES; MILK-DERIVED EXOSOMES; EXTRACELLULAR VESICLES; EPITHELIAL-CELLS; BREAST-MILK; DENDRITIC CELLS; TRANSFERRIN RECEPTOR; ANTIGEN PRESENTATION; QUANTITATIVE CHANGES; DEPENDENT MANNER;

D O I：

10.3389/fphar.2021.658505

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Exosomes are 30-150 nm sized vesicles released by a variety of cells, and are found in most physiological compartments (feces, blood, urine, saliva, breast milk). They can contain different cargo, including nucleic acids, proteins and lipids. In Inflammatory Bowel Disease (IBD), a distinct exosome profile can be detected in blood and fecal samples. In addition, circulating exosomes can carry targets on their surface for monoclonal antibodies used as IBD therapy. This review aims to understand the exosome profile in humans and other mammals, the cargo contained in them, the effect of exosomes on the gut, and the application of exosomes in IBD therapy.

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