The trithorax-group protein Lid is a histone H3 trimethyl-Lys4 demethylase

被引：76

作者：

Lee, Nara

Zhang, Junyu

Klose, Robert J.

Erdjument-Bromage, Hediye

Tempst, Paul

Jones, Richard S.

Zhang, Yi ^{[1
]}

机构：

[1] Univ N Carolina, Howard Hughes Med Inst, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, Dept Biochem & Biophys, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA

[3] So Methodist Univ, Dept Sci Biol, Dallas, TX 75275 USA

[4] Mem Sloan Kettering Canc Ctr, Mol Biol Program, New York, NY 10021 USA

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2007年 / 14卷 / 04期

关键词：

D O I：

10.1038/nsmb1216

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent studies have demonstrated that histone methylation can be dynamically regulated through active demethylation. However, no demethylase specific to histone H3 trimethyl-Lys4 (H3K4me3) has been identified. Here we report that the Drosophila melanogaster protein 'little imaginal discs' (Lid), a JmjC domain-containing trithorax group protein, can demethylate H3K4me3. Consistent with its genetic classification, Lid positively regulates Hox gene expression in S2 cells.

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页码：341 / 343

页数：3

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