RETRACTED: LOX-1-Mediated Effects on Vascular Cells in Atherosclerosis (Retracted Article)

被引：64

作者：

Chistiakov, Dimitry A. ^{[1
]}

Orekhov, Alexander N. ^{[2
,3
,4
]}

Bobryshev, Yuri V. ^{[4
,5
,6
]}

机构：

[1] Res Ctr Childrens Hlth, Dept Mol Genet Diagnost & Cell Biol, Div Lab Med, Inst Pediat, Moscow, Russia

[2] Russian Acad Sci, Inst Gen Pathol & Pathophysiol, Lab Angiopathol, Moscow, Russia

[3] Moscow MV Lomonosov State Univ, Fac Biol, Dept Biophys, Moscow, Russia

[4] Skolkovo Innovat Ctr, Atherosclerosis Res Inst, Moscow, Russia

[5] Univ New S Wales, Sch Med Sci, Fac Med, Sydney, NSW, Australia

[6] Univ Western Sydney, Sch Med, Campbelltown, NSW, Australia

来源：

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY | 2016年 / 38卷 / 05期

基金：

俄罗斯科学基金会;

关键词：

Atherosclerosis; Atherogenesis; Arteries; Lectin-like oxidized low-density lipoprotein receptor-1; LOX-1; Oxidized LDL; OxLDL; DENSITY-LIPOPROTEIN RECEPTOR-1; SMOOTH-MUSCLE-CELLS; OXIDIZED LDL RECEPTOR-1; LOX-1; EXPRESSION; OX-LDL; MURINE MACROPHAGES; ENDOTHELIAL-CELLS; ADHESION; LYSOPHOSPHATIDYLCHOLINE; APOPTOSIS;

D O I：

10.1159/000443123

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

In healthy arteries, expression of lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is almost undetectable. However, in proatherogenic conditions, LOX-1 is markedly up regulated in vascular cells. In atherosclerosis, LOX-1 appears to be the key scavenger receptor for binding oxidized LDL (oxLDL). Notably, a positive feedback exists between LOX-1 and oxLDL. LOX-1 is involved in mediating of proatherosclerotic effects of oxLDL which result in endothelial dysfunction, proinflammatory recruitment of monocytes into the arterial intima, formation of foam cells, apoptosis of endothelial cells (ECs) and vascular smooth muscle cells (VS MCs), as well as in plaque destabilization and rupture. In this review, we consider effects of the LOX-1/oxLDL axis on several types of vascular cells such as ECs, VS MCs, and macrophages. (C) 2016 The Author(s) Published by S. Karger AG, Basel

引用

页码：1851 / 1859

页数：9

共 46 条

[1]

LOX-1 mediates lysophosphatidylcholine-induced oxidized LDL uptake in smooth muscle cells [J].