Mitochondria optical parameters are dependent on their energy state: a new electrooptical effect?

被引：22

作者：

Tychinsky, V

Kretushev, A

Vyshenskaja, T

机构：

[1] Moscow State Inst Radioengn Elect & Automat, Moscow 117454, Russia

[2] Moscow MV Lomonosov State Univ, Fac Phys, Moscow 119899, Russia

来源：

EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS | 2004年 / 33卷 / 08期

关键词：

coherent phase microscopy; electrooptical effect in mitochondria; mitochondrion; transmembrane potential;

D O I：

10.1007/s00249-004-0414-3

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 [生物物理学];

摘要：

The membrane potential of mitochondria determines, to a large extent, their functional state and the response to the changing conditions of the environment. A correlation was found between the changes in the optical characteristics of isolated mitochondria and the composition of the incubation medium, which determines the potential of the inner mitochondrial membrane. The measurements performed by the method of coherent phase microscopy made it possible to establish a linear dependence of the phase height on the value of the membrane potential and to calculate the electrooptical constant, Kapproximate to(3-4)x10(-7) m/V.

引用

页码：700 / 705

页数：6

共 26 条

[1]

Mitochondria and cell death - Mechanistic aspects and methodological issues [J].