Inhibition of Pseudomonas aeruginosa biofilm formation with bromoageliferin analogues

被引：123

作者：

Huigens, Robert W., III

Richards, Justin J.

Parise, Gina

Ballard, T. Eric

Zeng, Wei

Deora, Rajendar

Melander, Christian

机构：

[1] N Carolina State Univ, Dept Chem, Raleigh, NC 27695 USA

[2] Wake Forest Univ Hlth Sci, Program Mol Genet, Winston Salem, NC 27157 USA

[3] Wake Forest Univ Hlth Sci, Dept Microbiol & Immunol, Winston Salem, NC 27157 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2007年 / 129卷 / 22期

关键词：

D O I：

10.1021/ja069017t

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Two analogues of the marine natural product bromoageliferin have been synthesized and subsequently assayed for the ability to inhibit the formation of Pseudomonas aeruginosa biofilms. Both compounds inhibited the ability of Pseudomonas aeruginosa strains PAO1 and PA14 to form biofilms; however, they displayed differential toxicity to planktonic bacteria. The cis analogue, CAGE, was found to possess greater toxicity than the trans analogue, TAGE. These compounds have no structural homology to any known inhibitors of Pseudomonas aeruginosa biofilms.

引用

页码：6966 / +

页数：3

共 16 条

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