Vancomycin-resistant enterococci - A road map on how to prevent the emergence and transmission of antimicrobial resistance

被引：71

作者：

DeLisle, S

Perl, TM

机构：

[1] US Vet Adm Med Ctr, Baltimore, MD USA

[2] Univ Maryland, Dept Internal Med, Baltimore, MD 21201 USA

[3] Univ Maryland, Dept Physiol, Div Pulm & Crit Care, Baltimore, MD 21201 USA

[4] Johns Hopkins Univ, Sch Med, Dept Hosp Epidemiol, Baltimore, MD USA

[5] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA

[6] Johns Hopkins Univ, Bloomberg Sch Publ Hlth & Hyg, Baltimore, MD 21205 USA

来源：

CHEST | 2003年 / 123卷 / 05期

关键词：

antibiotic control; antibiotic management; antibiotic stewardship; enterococcus; infection control; resistance; review; surveillance; vancomycin; vancomycin-resistant enterococci;

D O I：

10.1378/chest.123.5_suppl.504S

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Nosocomial acquisition of microorganisms resistant to multiple antibiotics represents a threat to patient safety. Here we review the mechanisms that have allowed highly resistant strains belonging to the Enterococcus genus to proliferate within our health-care institutions. These mechanisms indicate that decreasing the prevalence of resistant organisms requires active surveillance, adherence to vigorous isolation, hand hygiene and environmental decontamination measures, and effective antibiotic stewardship. We suggest how to tailor such a complex, multidisciplinary program to the needs of a particular health-care setting so as to maximize cost-effectiveness.

引用

页码：504S / 518S

页数：15

共 183 条

[1] Glycopeptide susceptibility among Danish Enterococcus faecium and Enterococcus faecalis isolates of animal and human origin and PCR identification of genes within the vanA cluster [J].