Y is there a risk to being male?

被引：34

作者：

Charchar, FJ

Tomaszewski, M

Strahorn, P

Champagne, B

Dominiczak, AF ^{[1
]}

机构：

[1] Univ Glasgow, Div Cardiovasc & Med Sci, BHF Glasgow Cardiovasc Res Ctr, Glasgow G11 6NT, Lanark, Scotland

[2] Med Univ Silesia, Dept Internal Med Diabetol & Nephrol, Zabrze, Poland

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2003年 / 14卷 / 04期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/S1043-2760(03)00032-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Being male or female can make a vital difference to many important biological functions and can lead to disparities in health. The Y chromosome carries the sex-determining sex reversal Y (SRY) gene and recent studies show that it might also harbor genes that have important biological functions other than sex determination. One such example is the emerging evidence from animal models and humans that supports the presence of cardiovascular genes on the Y chromosome. A significant amount of work remains to identify these genes; however, we report here observations linking the Y chromosome to hypertension, which could explain the higher incidence of cardiovascular disease in males compared with females.

引用

收藏

页码：163 / 168

页数：6

相关论文

共 40 条

[1] SHR Y chromosome enhances the nocturnal blood pressure in socially interacting rats [J].

Caplea, A ;

Seachrist, D ;

Dunphy, G ;

Ely, D .

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2000, 279 (01) :H58-H66

[2] Noradrenergic content and turnover rate in kidney and heart shows gender and strain differences [J].

Caplea, A ;

Seachrist, D ;

Daneshvar, H ;

Dunphy, G ;

Ely, D .

JOURNAL OF APPLIED PHYSIOLOGY, 2002, 92 (02) :567-571

[3] Sodium-induced rise in blood pressure is suppressed by androgen receptor blockade [J].

Caplea, A ;

Seachrist, D ;

Dunphy, G ;

Ely, D .

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2001, 280 (04) :H1793-H1801

[4]

Charchar FJ, 2002, HYPERTENSION, V40, P396

[5] The Y chromosome effect on blood pressure in two European populations [J].

Charchar, FJ ;

Tomaszewski, M ;

Padmanabhan, S ;

Lacka, B ;

Upton, MN ;

Inglis, GC ;

Anderson, NH ;

McConnachie, A ;

Zukowska-Szczechowska, E ;

Grzeszczak, W ;

Connell, JMC ;

Watt, GCM ;

Dominiczak, AF .

HYPERTENSION, 2002, 39 (02) :353-356

[6] BLOOD-PRESSURE IN GENETICALLY HYPERTENSIVE RATS - INFLUENCE OF THE Y-CHROMOSOME [J].

DAVIDSON, AO ;

SCHORK, N ;

JAQUES, BC ;

KELMAN, AW ;

SUTCLIFFE, RG ;

REID, JL ;

DOMINICZAK, AF .

HYPERTENSION, 1995, 26 (03) :452-459

[7] Sex hormones and hypertension [J].

Dubey, RK ;

Oparil, S ;

Imthurn, B ;

Jackson, EK .

CARDIOVASCULAR RESEARCH, 2002, 53 (03) :688-708

[8] Contribution of autosomal loci and the Y chromosome to the stress response in rats [J].

Dumas, P ;

Pausová, Z ;

Kren, V ;

Krenová, D ;

Pravenec, M ;

Dumont, M ;

Ely, D ;

Turner, M ;

Sun, YL ;

Tremblay, J ;

Hamet, P .

HYPERTENSION, 2000, 35 (02) :568-573

[9] Identification and chromosomal localization of ecogenetic components of electrolyte excretion [J].

Dumas, P ;

Kren, V ;

Krenová, D ;

Pravenec, M ;

Hamet, P ;

Tremblay, J .

JOURNAL OF HYPERTENSION, 2002, 20 (02) :209-217

[10] Association of the human Y chromosome with high blood pressure in the general population [J].

Ellis, JA ;

Stebbing, M ;

Harrap, SB .

HYPERTENSION, 2000, 36 (05) :731-733

← 1 2 3 4 →