PGC-1α at the crossroads of type 2 diabetes

被引：40

作者：

Attie, AD ^{[1
]}

Kendziorski, CM

机构：

[1] Univ Wisconsin, Dept Biochem, Madison, WI 53706 USA

[2] Univ Wisconsin, Dept Biostat & Med Informat, Madison, WI 53706 USA

来源：

NATURE GENETICS | 2003年 / 34卷 / 03期

关键词：

D O I：

10.1038/ng0703-244

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Muscle mitochondrial respiratory metabolism is reduced in aging and diabetes. Now, coordinated changes in expression of genes involved in oxidative phosphorylation have been found in individuals with type 2 diabetes mellitus (DM2). Peroxisome proliferator activator protein-gamma co-activator-1alpha (PGC-1alpha) seems to be in charge of this orchestrated change in gene expression.

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收藏

页码：244 / 245

页数：2

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