Canthaxanthin induces apoptosis in human cancer cell lines

被引:72
作者
Palozza, P
Maggiano, N
Calviello, G
Lanza, P
Piccioni, E
Ranelletti, FO
Bartoli, GM
机构
[1] Univ Cattolica Sacro Cuore, Inst Gen Pathol, I-00168 Rome, Italy
[2] Univ Cattolica Sacro Cuore, Inst Pathol, I-00168 Rome, Italy
[3] Univ Cattolica Sacro Cuore, Inst Histol, I-00168 Rome, Italy
[4] Univ Roma Tor Vergata, Dept Biol, I-00133 Rome, Italy
关键词
D O I
10.1093/carcin/19.2.373
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
To investigate the possibility that canthaxanthin inhibits cancer cell growth by inducing apoptosis, human WiDr colon adenocarcinoma and SK-MEL-2 melanoma cells were treated with two different doses of the carotenoid for 48 h, Canthaxanthin was incorporated and/or associated to cells, The treatment with the carotenoid caused growth inhibition in both cell types. Concomitantly, apoptosis was induced, Increasing time of exposure and carotenoid concentration, this effect was more pronounced. At 48 h, the percentages of apoptotic cells were 13 and 15, using 1 mu M canthaxanthin, and 18 and 20, using 10 mu M canthaxanthin in WiDr and SK-MEL-2 cells, respectively. This study represents the first demonstration that canthaxanthin is able to induce apoptosis in tumour cells.
引用
收藏
页码:373 / 376
页数:4
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