Serum C-reactive protein concentration and lower urinary tract symptoms in older men in the Third National Health and Nutrition Examination Survey (NHANES III)

被引:76
作者
Rohrmann, S
De Marzo, AM
Smit, E
Giovannucci, E
Platz, EA
机构
[1] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD 21205 USA
[2] Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21205 USA
[3] Johns Hopkins Med Inst, Sidney Kimmel Comprehen Canc Ctr, Baltimore, MD 21205 USA
[4] Johns Hopkins Med Inst, James Buchanan Brady Urol Inst, Baltimore, MD 21205 USA
[5] SUNY Buffalo, Univ Buffalo, Sch Publ Hlth & Hlth Profess, Buffalo, NY 14260 USA
[6] Harvard Univ, Brigham & Womens Hosp, Channing Lab, Boston, MA 02115 USA
[7] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA
[8] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA
关键词
C-reactive protein; lower urinary tract symptoms; older men; NHANES III;
D O I
10.1002/pros.20110
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
BACKGROUND. Inflammatory infiltrates are frequently found in and around nodules in benign prostate hyperplasia (BPH). We examined cross-sectionally the association of serum C-reactive protein concentration, a non-specific marker of inflammation, and lower urinary tract symptoms (LUTS), suggestive of BPH. METHODS. We included 2,337 men, 60 years and older, who participated in the Third National Health and Examination Survey (NHANES III) between 1988 and 1994. As part of NHANES III, serum C-reactive protein concentration was measured and men reported whether they currently experienced nocturia, incomplete emptying, hesitancy, or weak stream as well as whether they had had non-cancer prostate surgery in the past. All results were weighted to account for sampling probability in NHANES III. RESULTS. Age-adjusted and weighted mean serum C-reactive protein concentration was 0.32 mg/dl in men without symptoms and without surgery, 0.35 mg/dl in men with three or four symptoms (P = 0.06), and 0.36 mg/dl in men with one or two symptoms (P = 0.06). After adjusting for age and race and excluding men with an acute infection, men with a C-reactive protein concentration above the limit of detection (>0.30 mg/dl) were 1.47 times (95% CI 0.87-2.50) more likely to have three or four symptoms than men with a C-reactive protein concentration below the detection limit, although the association was not statistically significant. The association was not attenuated after adjusting for the metabolic syndrome, but was attenuated after excluding men with metabolic syndrome. CONCLUSIONS. These results suggest that elevated circulating C-reactive protein concentration might be an indicator of intraprostatic inflammation in symptomatic BPH. The presence of the metabolic syndrome might be a mediator of this association. (C) 2004 Wiley-Liss, Inc.
引用
收藏
页码:27 / 33
页数:7
相关论文
共 21 条
[1]   Characterisation of inflammatory cells in benign prostatic hyperplasia [J].
Anim, JT ;
Udo, C ;
John, B .
ACTA HISTOCHEMICA, 1998, 100 (04) :439-449
[2]   Prostatic infarction/infection in acute urinary retention secondary to benign prostatic hyperplasia [J].
Anjum, I ;
Ahmed, M ;
Azzopardi, A ;
Mufti, GR .
JOURNAL OF UROLOGY, 1998, 160 (03) :792-793
[3]  
[Anonymous], 1997, SOFTWARE STAT ANAL C
[4]  
[Anonymous], 1994, VITAL HLTH STAT, V1, P1
[5]   C-reactive protein and cardiovascular disease: a review of risk prediction and interventions [J].
de Ferranti, S ;
Rifai, N .
CLINICA CHIMICA ACTA, 2002, 317 (1-2) :1-15
[6]   Distribution of inflammation, pre-malignant lesions, incidental carcinoma in histologically confirmed benign prostatic hyperplasia: A retrospective analysis [J].
Di Silverio, F ;
Gentile, V ;
De Matteis, A ;
Mariotti, G ;
Giuseppe, V ;
Luigi, PA ;
Sciarra, A .
EUROPEAN UROLOGY, 2003, 43 (02) :164-175
[7]  
Drachenberg DE, 1999, PROSTATE, V41, P127, DOI 10.1002/(SICI)1097-0045(19991001)41:2<127::AID-PROS7>3.0.CO
[8]  
2-H
[9]   Distribution of chronic prostatitis in radical prostatectomy specimens with up-regulation of bcl-2 in areas of inflammation [J].
Gerstenbluth, RE ;
Seftel, AD ;
MacLennan, GT ;
Rao, RN ;
Corty, EW ;
Ferguson, K ;
Resnick, MI .
JOURNAL OF UROLOGY, 2002, 167 (05) :2267-2270
[10]   PLATELET-DERIVED GROWTH-FACTOR (PDGF), ANDROGENS AND INFLAMMATION - POSSIBLE ETIOLOGIC FACTORS IN THE DEVELOPMENT OF PROSTATIC HYPERPLASIA [J].
GLEASON, PE ;
JONES, JA ;
REGAN, JS ;
SALVAS, DB ;
EBLE, JN ;
LAMPH, WW ;
VLAHOS, CJ ;
HUANG, WL ;
FALCONE, JF ;
HIRSCH, KS .
JOURNAL OF UROLOGY, 1993, 149 (06) :1586-1592