Regulation of gonadotropin subunit gene transcription

被引：144

作者：

Burger, LL ^{[1
]}

Haisenleder, DJ

Dalkin, AC

Marshall, JC

机构：

[1] Univ Virginia, Div Endocrinol, Dept Internal Med, Charlottesville, VA 22908 USA

[2] Univ Virginia, Ctr Res Reprod, Charlottesville, VA 22908 USA

来源：

JOURNAL OF MOLECULAR ENDOCRINOLOGY | 2004年 / 33卷 / 03期

关键词：

D O I：

10.1677/jme.1.01600

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Reproductive function in mammals is regulated by the pituitary gonadotropins luteinizing hormone (LH) and follicle-stimulating hormone (FSH). LH and FSH are secreted by the gonadotrope cell and act on the gonad in a sequential and synergistic manner to initiate sexual maturation and maintain cyclic reproductive function. The synthesis and secretion of LH and FSH are regulated mainly by the pulsatile release of the hypothalamic decapeptide hormone gonadotropin-releasing hormone (GnRH). The control of differential LH and FSH synthesis and secretion is complex and involves the interplay between the gonads, hypothalamus and pituitary. In this review, the transcriptional regulation of the gonadotropin subunit genes is discussed in a physiologic setting, and we aimed to examine the mechanisms that drive those changes.

引用

页码：559 / 584

页数：26

共 212 条

[1] AN ALPHA-SUBUNIT-SECRETING CELL-LINE DERIVED FROM A MOUSE THYROTROPE TUMOR [J].

AKERBLOM, IE ;

RIDGWAY, EC ;

MELLON, PL .

MOLECULAR ENDOCRINOLOGY, 1990, 4 (04) :589-596

[2] Signal transduction pathways and transcription factors involved in the gonadotropin-releasing hormone-stimulated gonadotropin subunit gene expression [J].

Ando, H ;

Hew, CL ;

Urano, A .

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY, 2001, 129 (2-3) :525-532

[3] GONADOTROPIN-RELEASING-HORMONE STIMULATES MASS CHANGES IN PHOSPHOINOSITIDES AND DIACYLGLYCEROL ACCUMULATION IN PURIFIED GONADOTROPE CELL-CULTURES [J].

ANDREWS, WV ;

CONN, PM .

ENDOCRINOLOGY, 1986, 118 (03) :1148-1158

[4] DECAY OF FOLLICLE-STIMULATING HORMONE-BETA MESSENGER-RNA IN THE PRESENCE OF TRANSCRIPTIONAL INHIBITORS AND OR INHIBIN, ACTIVIN, OR FOLLISTATIN [J].

ATTARDI, B ;

WINTERS, SJ .

MOLECULAR ENDOCRINOLOGY, 1993, 7 (05) :668-680

[5] EFFECTS OF PROGESTERONE ON THE ESTRADIOL-INDUCED FOLLICLE-STIMULATING-HORMONE (FSH) SURGE AND FSH-BETA MESSENGER-RIBONUCLEIC-ACID IN THE RAT [J].

ATTARDI, B ;

FITZGERALD, T .

ENDOCRINOLOGY, 1990, 126 (05) :2281-2287

[6] COMPARISON OF THE EFFECTS OF CYCLOHEXIMIDE AND INHIBIN ON THE GONADOTROPIN SUBUNIT MESSENGER RIBONUCLEIC-ACIDS [J].

ATTARDI, B ;

KEEPING, HS ;

WINTERS, SJ ;

KOTSUJI, F ;

TROEN, P .

ENDOCRINOLOGY, 1991, 128 (01) :119-125

[7]

Attisano Liliana, 1996, Cytokine and Growth Factor Reviews, V7, P327, DOI 10.1016/S1359-6101(96)00042-1

[8] PULSATILE SECRETION OF LH, FSH, PROLACTIN, ESTRADIOL AND PROGESTERONE DURING THE HUMAN MENSTRUAL-CYCLE [J].

BACKSTROM, CT ;

MCNEILLY, AS ;

LEASK, RM ;

BAIRD, DT .

CLINICAL ENDOCRINOLOGY, 1982, 17 (01) :29-42

[9] Activin regulation of the follicle-stimulating hormone β-subunit gene involves Smads and the TALE homeodomain proteins Pbx1 and Prep1 [J].

Bailey, JS ;

Rave-Harel, N ;

McGillivray, SM ;

Coss, D ;

Mellon, PL .

MOLECULAR ENDOCRINOLOGY, 2004, 18 (05) :1158-1170

[10] Activin modulates differential effects of estradiol on synthesis and secretion of follicle-stimulating hormone in ovine pituitary cells [J].

Baratta, M ;

West, LA ;

Turzillo, AM ;

Nett, TM .

BIOLOGY OF REPRODUCTION, 2001, 64 (02) :714-719

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