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Anti-inflammatory actions of lipoxins

被引：3
作者：
Bannenberg, Gerard L. [1 ]
机构：
[1] CSIC, Dept Plant Mol Genet, Ctr Nacl Biotecnol, Madrid 28049, Spain
来源：
EXPERT OPINION ON THERAPEUTIC PATENTS | 2007年 / 17卷 / 06期
关键词：
anti-inflammatory; aspirin; inflammation; lipoxin; neutrophil; stable analogue;
D O I：
10.1517/13543776.17.6.591
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Efforts to understand and harness the potent anti-inflammatory and immunomodulating properties of the endogenous lipid mediators lipoxin A(4) (LXA(4)), lipoxin B-4 (LXB4) and the aspirin-triggered lipoxins, have resulted in a number of patent applications by both academic research groups and pharmaceutical companies. The patents cover the anti-inflammatory properties of lipoxins across a range of diseases with components of inflammation.
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收藏
页码：591 / 605
页数：15
相关论文
共 138 条
  • [1] ACADIA PHARM INC, 2005, Patent No. 05047899
  • [2] ALCON INC, 2003, Patent No. 6645978
  • [3] Lipoxin-mediated inhibition of IL-12 production by DCs: a mechanism for regulation of microbial immunity
    Aliberti, J
    Hieny, S
    Sousa, CRE
    Serhan, CN
    Sher, A
    [J]. NATURE IMMUNOLOGY, 2002, 3 (01) : 76 - 82
  • [4] [Anonymous], 2005, PROSTAGLANDINS LEUKO, V73, P139
  • [5] Aspirin-triggered lipoxin A4 and B4 analogs block extracellular signal-regulated kinase-dependent TNF-α secretion from human T cells
    Ariel, A
    Chiang, N
    Arita, M
    Petasis, NA
    Serhan, CN
    [J]. JOURNAL OF IMMUNOLOGY, 2003, 170 (12) : 6266 - 6272
  • [6] Cutting edge:: Lipoxin (LX) A4 and aspirin-triggered 15-Epi-LXA4 block allergen-induced eosinophil trafficking
    Bandeira-Melo, C
    Bozza, PT
    Diaz, BL
    Cordeiro, RSB
    Jose, PJ
    Martins, MA
    Serhan, CN
    [J]. JOURNAL OF IMMUNOLOGY, 2000, 164 (05) : 2267 - 2271
  • [7] Lipoxins and novel 15-epi-lipoxin analogs display potent anti-inflammatory actions after oral administration
    Bannenberg, G
    Moussignac, RL
    Gronert, K
    Devchand, PR
    Schmidt, BA
    Guilford, WJ
    Bauman, JG
    Subramanyam, B
    Perez, HD
    Parkinson, JF
    Serhan, CN
    [J]. BRITISH JOURNAL OF PHARMACOLOGY, 2004, 143 (01) : 43 - 52
  • [8] Molecular circuits of resolution: Formation and actions of resolvins and protectins
    Bannenberg, GL
    Chiang, N
    Ariel, A
    Arita, M
    Tjonahen, E
    Gotlinger, KH
    Hong, S
    Serhan, CN
    [J]. JOURNAL OF IMMUNOLOGY, 2005, 174 (07) : 4345 - 4355
  • [9] BAYER HEALTHCARE AG, 2007, Patent No. 1266005
  • [10] Bernard C., 1859, Lecons sur les proprietes physiologiques et les alterations pathologiques des liquides de l'organisme
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