Mitochondrial medicine: Pharmacological targeting of mitochondria in disease

被引：191

作者：

Armstrong, J. S. ^{[1
]}

机构：

[1] Natl Univ Singapore, Dept Biochem, Yong Loo Lin Sch Med, Fac Med, Singapore 117597, Singapore

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 2007年 / 151卷 / 08期

关键词：

mitochondria; cancer; diabetes; neurodegenerative disease; ischaemia-reperfusion; DLC; SS peptide; DLQsome; drug targeting;

D O I：

10.1038/sj.bjp.0707288

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Mitochondria play a central role in cell life and death and are known to be important in a wide range of diseases including the cancer, diabetes, cardiovascular disease, and the age-related neurodegenerative diseases. The unique structural and functional characteristics of mitochondria enable the selective targeting of drugs designed to modulate the function of this organelle for therapeutic gain. This review discusses mitochondrial drug targeting strategies and a variety of novel mitochondrial drug targets including the electron transport chain, mitochondrial permeability transition, Bcl-2 family proteins and mitochondrial DNA. Mitochondrial drug-targeting strategies will open up avenues for manipulating mitochondrial functions and allow for selective protection or eradication of cells for therapeutic gain in a variety of diseases.

引用

页码：1154 / 1165

页数：12

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