Pure red cell aplasia after allogeneic stem cell transplantation with reduced conditioning

被引：23

作者：

Veelken, H ^{[1
]}

Wäsch, R ^{[1
]}

Behringer, D ^{[1
]}

Bertz, H ^{[1
]}

Finke, J ^{[1
]}

机构：

[1] Univ Freiburg, Med Ctr, Dept Hematol Oncol, D-79106 Freiburg, Germany

来源：

BONE MARROW TRANSPLANTATION | 2000年 / 26卷 / 08期

关键词：

red cell aplasia; reduced conditioning; isoagglutinins; fludarabine;

D O I：

10.1038/sj.bmt.1702629

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Conditioning regimens with reduced intensity are used increasingly for allogeneic stem cell transplantation in elderly or extensively pretreated patients, Two cases of pure red cell aplasia after fludarabine-based conditioning and during immunosuppression with cyclosporin are described. Both patients received ABO-mismatched stem cells and had anti-donor isoagglutinins. Red cell recovery occurred after extended immunosuppression when isoagglutinins had disappeared. Colony assays indicated serologic suppression of the erythrocyte lineage in one patient. Since reduced conditioning permits donor cell engraftment primarily by suppression of host T cells, antibody-mediated immunological complications may occur more frequently than after 'classical' conditioning.

引用

页码：911 / 915

页数：5

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