Orphanin FQ/nociceptin in the ventromedial nucleus facilitates lordosis in female rats

被引：61

作者：

Sinchak, K ^{[1
]}

Hendricks, DG

Baroudi, R

Micevych, PE

机构：

[1] Univ Calif Los Angeles, Sch Med, Mental Retardat Res Ctr, Dept Neurobiol, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Sch Med, Brain Res Inst, Neuroendocrinol Lab, Los Angeles, CA 90095 USA

来源：

NEUROREPORT | 1997年 / 8卷 / 18期

关键词：

estrogen; nociceptin; OFQ; ophanin FQ; opioid receptor-like receptor; opioids; ORL-1; receptor immunocytochemistry; sexual receptivity; VMH;

D O I：

10.1097/00001756-199712220-00004

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

THE localization of opioid receptor-like (ORL-1) orphan receptor in the ventromedial nucleus of the hypothalamus (VMH) suggested a role for this opioid system in the regulation of lordosis behavior. Recently, the ligand for ORL-1, orphanin FQ/nociceptin (OFQ/N), has been characterized and also demonstrated to be present in the VMH. The present experiments examined whether OFQ/N in the VMH facilitates lordosis behavior in estrogen-primed, sexually unreceptive female rats, and whether estrogen regulates ORL-1 levels in the VMH. Estrogen was shown to increase ORL-1 immunoreactivity in the VMH, and microinfusions of OFQ/N into the VMH facilitated lordosis behavior in a dose-dependent manner.

引用

页码：3857 / 3860

页数：4

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