Phosphorylation of the cap-binding protein eIF4E by the MAPK-activated protein kinase Mnk1

被引：89

作者：

Pyronnet, S ^{[1
]}

机构：

[1] McGill Univ, Dept Biochem, Montreal, PQ H3G 1Y6, Canada

来源：

BIOCHEMICAL PHARMACOLOGY | 2000年 / 60卷 / 08期

关键词：

translation initiation; cap binding protein; Mnk1; phosphorylation; cell cycle;

D O I：

10.1016/S0006-2952(00)00429-9

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The purpose of this review is to summarize recent experimental data describing the regulation of the phosphorylation of eIF4E, the cap-binding protein, by the MAPK-activated protein kinase Mnk1. Mnk1 does not interact directly with eIF4E, but uses a docking site in eIF4G, a partner of eIF4E. Consequently, control of eIF4E phosphorylation may not strictly depend on changes in Mnk1 activity. The possibility that integrity of the eIF4E/eIF4G/Mnk1 complex also impinges upon eIF4E phosphorylation is discussed. BIOCHEM PHARMACOL 60;8:1237-1243, 2000. (C) 2000 Elsevier Science Inc.

引用

页码：1237 / 1243

页数：7

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