Synergic activity of fluoroquinolones and linezolid against Mycobacterium tuberculosis

被引：30

作者：

Díaz, JCR ^{[1
]}

Ruiz, M ^{[1
]}

López, M ^{[1
]}

Royo, G ^{[1
]}

机构：

[1] Univ Miguel Hernandez, Hosp Gen Univ Elche, Secc Microbiol, Alicante 03203, Spain

来源：

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | 2003年 / 21卷 / 04期

关键词：

D O I：

10.1016/S0924-8579(02)00387-4

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

We evaluated the in vitro activity against Mycobacterium tuberculosis of the combination of fluoroquinolones and linezolid with classical drugs. The combination of isoniazid with fluoroquinolones had synergic activity in nine of the ten isoniazid-susceptible strains. We also found synergism between rifampicin and linezolid in Five of the 15 strains susceptible to rifampicin. The clinical significance of these findings should be evaluated. (C) 2002 Elsevier Science B.V. and the International Society of Chemotherapy. All rights reserved.

引用

页码：354 / 356

页数：3

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