Active lifestyles moderate clinical outcomes in autosomal dominant frontotemporal degeneration

被引：39

作者：

Casaletto, K. B. ^{[1
]}

Staffaroni, A. M. ^{[1
]}

Wolf, A. ^{[1
]}

Appleby, B. ^{[2
]}

Brushaber, D. ^{[3
]}

Coppola, G. ^{[4
]}

Dickerson, B. ^{[5
]}

Domoto-Reilly, K. ^{[6
]}

Elahi, F. M. ^{[1
]}

Fields, J. ^{[3
]}

Fong, J. C. ^{[1
]}

Forsberg, L. ^{[2
]}

Ghoshal, N. ^{[7
]}

Graff-Radford, N. ^{[3
]}

Grossman, M. ^{[8
]}

Heuer, H. W. ^{[1
]}

Hsiung, G. -Y. ^{[9
]}

Huey, E. D. ^{[10
]}

Irwin, D. ^{[8
]}

Kantarci, K. ^{[3
]}

Kaufer, D. ^{[11
]}

Kerwin, D. ^{[12
]}

Knopman, D. ^{[3
]}

Kornak, J. ^{[13
]}

Kramer, J. H. ^{[1
]}

Litvan, I. ^{[14
]}

Mackenzie, I. R. ^{[9
]}

Mendez, M. ^{[4
]}

Miller, B. ^{[1
]}

Rademakers, R. ^{[15
]}

Ramos, E. M. ^{[16
]}

Rascovsky, K. ^{[8
]}

Roberson, E. D. ^{[17
]}

Syrjanen, J. A. ^{[3
]}

Tartaglia, M. C. ^{[18
]}

Weintraub, S. ^{[19
]}

Boeve, B. ^{[3
]}

Boxer, A. L. ^{[1
]}

Rosen, H. ^{[1
]}

Yaffe, K. ^{[20
]}

机构：

[1] Univ Calif San Francisco, Dept Neurol, Memory & Aging Ctr, 675 Nelson Rising Lane,Suite 190, San Francisco, CA 94158 USA

[2] Case Western Reserve Univ, Cleveland, OH 44106 USA

[3] Mayo Clin, Rochester, MN USA

[4] Univ Calif Los Angeles, Los Angeles, CA USA

[5] Harvard Med Sch, Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02115 USA

[6] Univ Washington, Seattle, WA 98195 USA

[7] Washington Univ, St Louis, IL USA

[8] Univ Penn, Philadelphia, PA 19104 USA

[9] Univ British Columbia, Vancouver, BC, Canada

[10] Columbia Univ, New York, NY USA

[11] Univ N Carolina, Chapel Hill, NC 27515 USA

[12] Univ Texas Southwestern, Dallas, TX USA

[13] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA USA

[14] Univ Calif San Diego, Dept Neurosci, Parkinson & Other Movement Disorder Ctr, San Diego, CA 92103 USA

[15] Mayo Clin, Jacksonville, FL 32224 USA

[16] Univ Calif Los Angeles, Los Angeles, CA USA

[17] Univ Alabama Birmingham, Birmingham, AL USA

[18] Univ Toronto, Toronto, ON, Canada

[19] Northwestern Univ, Mesulam Ctr Cognit Neurol & Alzheimers Dis, Chicago, IL 60611 USA

[20] Univ Calif San Francisco, San Francisco Dept Psychiat, San Francisco, CA 94143 USA

来源：

ALZHEIMERS & DEMENTIA | 2020年 / 16卷 / 01期

基金：

加拿大健康研究院;

关键词：

cognitive activity; cognitive reserve; exercise; frontotemporal dementia; physical activity; PHYSICAL-ACTIVITY SCALE; COGNITIVE IMPAIRMENT; ELDERLY PASE; ENVIRONMENTAL ENRICHMENT; ALZHEIMER-DISEASE; AMYLOID-BETA; OLDER-ADULTS; DEMENTIA; RISK; RESERVE;

D O I：

10.1002/alz.12001

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

Introduction: Leisure activities impact brain aging and may be prevention targets. We characterized how physical and cognitive activities relate to brain health for the first time in autosomal dominant frontotemporal lobar degeneration (FTLD). Methods: A total of 105 mutation carriers (C9orf72/MAPT/GRN) and 69 non-carriers reported current physical and cognitive activities at baseline. and completed longitudinal neurobehavioral assessments and brain magnetic resonance imaging(MRI) scans. Results: Greater physical and cognitive activities were each associated with an estimated >55% slower clinical decline per year among dominant gene carriers. There was also an interaction between leisure activities and frontotemporal atrophy on cognition in mutation carriers. High-activity carriers with frontotemporal atrophy (-1 standard deviation/year) demonstrated >two-fold better cognitive performances per year compared to their less active peers with comparable atrophy rates. Discussion: Active lifestyles were associated with less functional decline and moderated brain-to-behavior relationships longitudinally. More active carriers "outperformed" brain volume, commensurate with a cognitive reserve hypothesis. Lifestyle may confer clinical resilience, even in autosomal dominant FTLD.

引用

页码：91 / 105

页数：15

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