Corticosterone strongly increases the affinity of dorsal raphe 5-HTIA receptors

被引：17

作者：

Bellido, I ^{[1
]}

Hansson, AC

Gómez-Luque, AJ

Andbjer, B

Agnati, LF

Fuxe, K

机构：

[1] Univ Malaga, Sch Med, Dept Clin Pharmacol & Therapeut, E-29071 Malaga, Spain

[2] Karolinska Inst, Dept Neurosci, SE-17177 Stockholm, Sweden

[3] Karolinska Inst, Dept Neurotec, SE-17177 Stockholm, Sweden

[4] Univ Modena, Dept Biomed Sci, I-41100 Modena, Italy

来源：

NEUROREPORT | 2004年 / 15卷 / 09期

关键词：

corticosterone; dorsal raphe; galanin; 5-HTIA;

D O I：

10.1097/01.wnr.0000130542.06764.7f

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of corticosterone (10 mg/kg, s.c., 6 h) on dorsal raphe 5-HT1A autoreceptors have been studied in adrenalectomized rats with or without porcine galanin modulation. Adrenalectomy diminishes 5-HT1A autoreceptors affinity. Corticosterone increases 5-HT1A autoreceptor agonist affinity (+90%, p<0.001) in adrenalectomized rats. Galanin (10 nM) increases dorsal raphe 5-HT1A autoreceptor density (+65%, p<0.05) and its K-d value (+248%, p<0.05) only in adrenalectomized rats treated with corticosterone. Dorsal raphe glucocorticoid receptors activation by corticosterone may therefore lead to an increased signalling of 5-HT1A autoreceptors that may become counteracted by galanin receptor activation. Glucocorticoids, by enhancing dorsal raphe 5-HT1A autoreceptor function, may therefore cause reduced 5-HT neuronal activity and thus lead to a depressive state.

引用

页码：1457 / 1459

页数：3

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