Signaling by ROS drives inflammasome activation

被引：530

作者：

Martinon, Fabio ^{[1
]}

机构：

[1] Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 2010年 / 40卷 / 03期

关键词：

Danger signals; Inflammasome; Inflammation; Oxidative stress; NALP3; INFLAMMASOME; REACTIVE OXYGEN; OXIDATIVE STRESS; FREE-RADICALS; MACROPHAGES; IMMUNITY; INNATE; RELEASE; SILICA; ACID;

D O I：

10.1002/eji.200940168

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Inflammasomes are innate immune signaling pathways that sense pathogens and injury to direct the proteolytic maturation of inflammatory cytokines such as IL-1 beta and IL-18. Among inflammasomes, the NLRP3/NALP3 inflammasome is the most studied. However, little is known on the molecular mechanisms that mediate its assembly and activation. Recent findings suggest that ROS are produced by NLRP3/NALP3 activators and are essential secondary messengers signaling NLRP3/NALP3 inflammasome activation.

引用

页码：616 / 619

页数：4

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