Nanocomposites with Spatially Separated Functionalities for Combined Imaging and Magnetolytic Therapy

被引：257

作者：

Hu, Shang-Hsiu ^{[1
,2
]}

Gao, Xiaohu ^{[1
]}

机构：

[1] Univ Washington, Dept Bioengn, Seattle, WA 98195 USA

[2] Natl Chiao Tung Univ, Dept Mat Sci & Engn, Hsinchu, Taiwan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2010年 / 132卷 / 21期

基金：

美国国家科学基金会;

关键词：

MAGNETIC NANOPARTICLES; PHASE-SEPARATION; JANUS PARTICLES; DESIGN;

D O I：

10.1021/ja102489q

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Compact nanostructures with highly integrated functionalities are of considerable current interest to drug delivery, multimodality imaging, and electronic devices. A key challenge, however, is how to combine individual components together without interfering or sacrificing their original electronic and optical properties. Here, we demonstrate a new class of nanocomposites with spatially separated functionalities. We further demonstrate magnetic field modulated imaging and an innovative application of this technology in cancer cell treatment, magnetolytic therapy, based on magnetically controlled mechanical damage to cell membranes.

引用

收藏

页码：7234 / +

页数：5

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