Mutated 5,10-methylenetetrahydrofolate reductase, hyperhomocysteinemia and risk for cardiovascular disease. Nature, nurture or nonsense?

被引:3
作者
Blom, HJ [1 ]
机构
[1] Univ Med Ctr Nijmegen, Dept Pediat, Lab Pediat & Neurol, NL-6500 HB Nijmegen, Netherlands
关键词
D O I
10.1046/j.1365-2362.2001.00759.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
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页码:6 / 8
页数:3
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共 19 条
[1]   A common mutation in the methylenetetrahydrofolate reductase gene is associated with an accumulation of formylated tetrahydrofolates in red blood cells [J].
Bagley, PJ ;
Selhub, J .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (22) :13217-13220
[2]  
Blom HJ, 2000, CIRCULATION, V101, pE171
[3]   A QUANTITATIVE ASSESSMENT OF PLASMA HOMOCYSTEINE AS A RISK FACTOR FOR VASCULAR-DISEASE - PROBABLE BENEFITS OF INCREASING FOLIC-ACID INTAKES [J].
BOUSHEY, CJ ;
BERESFORD, SAA ;
OMENN, GS ;
MOTULSKY, AG .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1995, 274 (13) :1049-1057
[4]   Common methylenetetrahydrofolate reductase gene mutation leads to hyperhomocysteinemia but not to vascular disease -: The result of a meta-analysis [J].
Brattström, L ;
Wilcken, DEL ;
Öhrvik, J ;
Brudin, L .
CIRCULATION, 1998, 98 (23) :2520-2526
[5]   Folate intake in Europe: recommended, actual and desired intake [J].
deBree, A ;
vanDusseldorp, M ;
Brouwer, IA ;
vanhetHof, KH ;
SteegersTheunissen, RPM .
EUROPEAN JOURNAL OF CLINICAL NUTRITION, 1997, 51 (10) :643-660
[6]  
ENGBERSEN AMT, 1995, AM J HUM GENET, V56, P142
[7]   A CANDIDATE GENETIC RISK FACTOR FOR VASCULAR-DISEASE - A COMMON MUTATION IN METHYLENETETRAHYDROFOLATE REDUCTASE [J].
FROSST, P ;
BLOM, HJ ;
MILOS, R ;
GOYETTE, P ;
SHEPPARD, CA ;
MATTHEWS, RG ;
BOERS, GJH ;
DENHEIJER, M ;
KLUIJTMANS, LAJ ;
VANDENHEUVEL, LP ;
ROZEN, R .
NATURE GENETICS, 1995, 10 (01) :111-113
[8]   HUMAN METHYLENETETRAHYDROFOLATE REDUCTASE - ISOLATION OF CDNA, MAPPING AND MUTATION IDENTIFICATION [J].
GOYETTE, P ;
SUMNER, JS ;
MILOS, R ;
DUNCAN, AMV ;
ROSENBLATT, DS ;
MATTHEWS, RG ;
ROZEN, R .
NATURE GENETICS, 1994, 7 (02) :195-200
[9]   Plasma homocysteine as a risk factor for vascular disease - The European concerted action project [J].
Graham, IM ;
Daly, LE ;
Refsum, HM ;
Robinson, K ;
Brattstrom, LE ;
Ueland, PM ;
PalmaReis, RJ ;
Boers, GHJ ;
Sheahan, RG ;
Israelsson, B ;
Uiterwaal, CS ;
Meleady, R ;
McMaster, D ;
Verhoef, P ;
Witteman, J ;
Rubba, P ;
Bellet, H ;
Wautrecht, JC ;
deValk, HW ;
Luis, ACS ;
ParrotRoulaud, FM ;
Tan, KS ;
Higgins, I ;
Garcon, D ;
Medrano, MJ ;
Candito, M ;
Evans, AE ;
Andria, G .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1997, 277 (22) :1775-1781
[10]  
KANG SS, 1988, AM J HUM GENET, V43, P414