The reaction between nitrite and hemoglobin: the role of nitrite in hemoglobin-mediated hypoxic vasodilation

被引：141

作者：

Kim-Shapiro, DB

Gladwin, MT

Patel, RP

Hogg, N

机构：

[1] Med Coll Wisconsin, Dept Biophys, Milwaukee, WI 53226 USA

[2] Med Coll Wisconsin, Free Rad Res Ctr, Milwaukee, WI 53226 USA

[3] Wake Forest Univ, Dept Phys, Winston Salem, NC 27109 USA

[4] NIDDK, Dept Crit Care Med, Biol Chem Lab, NIH, Bethesda, MD USA

[5] Univ Alabama, Dept Pathol, Birmingham, AL 35294 USA

[6] Univ Alabama, Ctr Free Rad Biol, Birmingham, AL 35294 USA

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 2005年 / 99卷 / 01期

关键词：

nitrite; hemoglobin; hypoxia; vasodilation;

D O I：

10.1016/j.jinorgbio.2004.10.034

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The reaction between nitrite and hemoglobin has been studied for over a century. However, recent evidence indicating nitrite is a latent vasodilatory agent that can be activated by its reaction with deoxyhemoglobin has led to renewed interest in this reaction. In this review we survey, in the context of our own recent studies, the chemical reactivity of nitrite with oxyhemoglobin, deoxyhemoglobin and methemoglobin, and place these reactions in both a physiological and pharmacological/therapeutic context. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：237 / 246

页数：10

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