Limonene Exerts Antiproliferative Effects and Increases Nitric Oxide Levels on a Lymphoma Cell Line by Dual Mechanism of the ERK Pathway: Relationship with Oxidative Stress

被引：37

作者：

Gabriela Manuele, Maria ^{[1
]}

Barreiro Arcos, Maria Laura ^{[3
]}

Davicino, Roberto ^{[1
]}

Ferraro, Graciela ^{[1
,2
]}

Cremaschi, Graciela ^{[3
]}

Anesini, Claudia ^{[1
,2
]}

机构：

[1] IQUIMEFA CONICET, Buenos Aires, DF, Argentina

[2] UBA, Fac Pharm & Biochem, Pharmacognosy Chair, Buenos Aires, DF, Argentina

[3] CEFYBO CONICET, Buenos Aires, DF, Argentina

来源：

CANCER INVESTIGATION | 2010年 / 28卷 / 02期

关键词：

Lymphoma; Limonene; Oxidative stress; Nitric oxide; NF-KAPPA-B; GLUTATHIONE-PEROXIDASE; SUPEROXIDE-DISMUTASE; INDUCED APOPTOSIS; SYNTHASE ACTIVITY; CYCLE ARREST; TUMOR-CELLS; K-RAS; INHIBITION; MONOTERPENES;

D O I：

10.3109/07357900903179583

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

D-limonene is a common monoterpene found in nature. Previously, it has been demonstrated that it has antiproliferative effects on a lymphoma cell line by increasing the nitric oxide (NO) level. In the present work this mechanism is analyzed by evaluating the participation of MAP38 and ERK pathways. Limonene increased the NO levels by inducing cell apoptosis by two mechanisms: through the production of H2O2 and ERK pathway activation at low concentrations, and through the inhibition of farnesylation of proteins and O-2(-) production at high concentrations. Both mechanisms were related to the increase in total nitrites, and the production of oxidative stress intermediates was involved.

引用

页码：135 / 145

页数：11

共 48 条

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[2]

Inducible nitric oxide synthase and proinflammatory cytokine expression by human keratinocytes during acute urticaria [J].