Urgent need for pragmatic trial platforms in severe asthma

被引：15

作者：

Pilette, Charles ^{[1
,2
]}

Brightling, Chris ^{[3
]}

Lacombe, Denis ^{[4
]}

Brusselle, Guy ^{[5
,6
,7
]}

机构：

[1] Catholic Univ Louvain, Dept Pneumol, Clin Univ St Luc, Brussels, Belgium

[2] Catholic Univ Louvain, Pole Pneumol ENT & Dermatol, Inst Rech Expt & Clin, Brussels, Belgium

[3] Univ Leicester, Leicester Natl Inst Hlth Res, Biomed Res Ctr, Leicester, Leics, England

[4] European Org Res Treatment Canc, Brussels, Belgium

[5] Ghent Univ Hosp, Dept Resp Med, Ghent, Belgium

[6] Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands

[7] Erasmus MC, Dept Resp Med, Rotterdam, Netherlands

来源：

LANCET RESPIRATORY MEDICINE | 2018年 / 6卷 / 08期

关键词：

SEVERE EOSINOPHILIC ASTHMA; MEPOLIZUMAB; PHENOTYPES;

D O I：

10.1016/S2213-2600(18)30291-1

中图分类号：

R4 [临床医学];

学科分类号：

100218 [急诊医学];

摘要：

引用

页码：581 / 583

页数：4

共 11 条

[1]

Dupilumab Efficacy and Safety in Moderate-to-Severe Uncontrolled Asthma [J].

Castro, M. ;

Corren, J. ;

Pavord, I. D. ;

Maspero, J. ;

Wenzel, S. ;

Rabe, K. F. ;

Busse, W. W. ;

Ford, L. ;

Sher, L. ;

FitzGerald, J. M. ;

Katelaris, C. ;

Tohda, Y. ;

Zhang, B. ;

Staudinger, H. ;

Pirozzi, G. ;

Amin, N. ;

Ruddy, M. ;

Akinlade, B. ;

Khan, A. ;

Chao, J. ;

Martincova, R. ;

Graham, N. M. H. ;

Hamilton, J. D. ;

Swanson, B. N. ;

Stahl, N. ;

Yancopoulos, G. D. ;

Teper, A. .

NEW ENGLAND JOURNAL OF MEDICINE, 2018, 378 (26) :2486-2496

[2]

International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma [J].

Chung, Kian Fan ;

Wenzel, Sally E. ;

Brozek, Jan L. ;

Bush, Andrew ;

Castro, Mario ;

Sterk, Peter J. ;

Adcock, Ian M. ;

Bateman, Eric D. ;

Bel, Elisabeth H. ;

Bleecker, Eugene R. ;

Boulet, Louis-Philippe ;

Brightling, Christopher ;

Chanez, Pascal ;

Dahlen, Sven-Erik ;

Djukanovic, Ratko ;

Frey, Urs ;

Gaga, Mina ;

Gibson, Peter ;

Hamid, Qutayba ;

Jajour, Nizar N. ;

Mauad, Thais ;

Sorkness, Ronald L. ;

Teague, W. Gerald .

EUROPEAN RESPIRATORY JOURNAL, 2014, 43 (02) :343-373

[3]

Tezepelumab in Adults with Uncontrolled Asthma [J].

Corren, Jonathan ;

Parnes, Jane R. ;

Wang, Liangwei ;

Mo, May ;

Roseti, Stephanie L. ;

Griffiths, Janet M. ;

van der Merwe, Rene .

NEW ENGLAND JOURNAL OF MEDICINE, 2017, 377 (10) :936-946

[4]

Drazen JM, 2018, N ENGL J MED

[5]

Benefits of omalizumab as add-on therapy in patients with severe persistent asthma who are inadequately controlled despite best available therapy (GINA 2002 step 4 treatment):: INNOVATE [J].

Humbert, M ;

Beasley, R ;

Ayres, J ;

Slavin, R ;

Hébert, J ;

Bousquet, J ;

Beeh, KM ;

Ramos, S ;

Canonica, GW ;

Hedgecock, S ;

Fox, H ;

Blogg, M ;

Surrey, K .

ALLERGY, 2005, 60 (03) :309-316

[6]

Mepolizumab Treatment in Patients with Severe Eosinophilic Asthma [J].

Ortega, Hector G. ;

Liu, Mark C. ;

Pavord, Ian D. ;

Brusselle, Guy G. ;

FitzGerald, J. Mark ;

Chetta, Alfredo ;

Humbert, Marc ;

Katz, Lynn E. ;

Keene, Oliver N. ;

Yancey, Steven W. ;

Chanez, Pascal .

NEW ENGLAND JOURNAL OF MEDICINE, 2014, 371 (13) :1198-1207

[7]

Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trial [J].

Pavord, Ian D. ;

Korn, Stephanie ;

Howarth, Peter ;

Bleecker, Eugene R. ;

Buhl, Roland ;

Keene, Oliver N. ;

Ortega, Hector ;

Chanez, Pascal .

LANCET, 2012, 380 (9842) :651-659

[8]

Integrating real-life studies in the global therapeutic research framework [J].

Roche, Nicolas ;

Reddel, Helen K. ;

Agusti, Alvar ;

Bateman, Eric D. ;

Krishnan, Jerry A. ;

Martin, Richard J. ;

Papi, Alberto ;

Postma, Dirkje ;

Thomas, Mike ;

Brusselle, Guy ;

Israel, Elliot ;

Rand, Cynthia ;

Chisholm, Alison ;

Price, David .

LANCET RESPIRATORY MEDICINE, 2013, 1 (10) :E29-E30

[9]

Heterogeneity of phenotypes in severe asthmatics. The Belgian Severe Asthma Registry (BSAR) [J].

Schleich, F. ;

Brusselle, G. ;

Louis, R. ;

Vandenplas, O. ;

Michils, A. ;

Pilette, C. ;

Peche, R. ;

Manise, M. ;

Joos, G. .

RESPIRATORY MEDICINE, 2014, 108 (12) :1723-1732

[10]

Global, regional, and national deaths, prevalence, disability-adjusted life years, and years lived with disability for chronic obstructive pulmonary disease and asthma, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015 [J].

Soriano, Joan B. ;

Abajobir, Amanuel Alemu ;

Abate, Kalkidan Hassen ;

Abera, Semaw Ferede ;

Agrawal, Anurag ;

Ahmed, Muktar Beshir ;

Aichour, Amani Nidhal ;

Aichour, Ibtihel ;

Aichour, Miloud Taki Eddine ;

Alam, Khurshid ;

Alam, Noore ;

Alkaabi, Juma M. ;

Al-Maskari, Fatma ;

Alvis-Guzman, Nelson ;

Amberbir, Alemayehu ;

Amoako, Yaw Ampem ;

Ansha, Mustafa Geleto ;

Anto, Josep M. ;

Asayesh, Hamid ;

Atey, Tesfay Mehari ;

Avokpaho, Euripide Frinel G. Arthur ;

Barac, Aleksandra ;

Basu, Sanjay ;

Bedi, Neeraj ;

Bensenor, Isabela M. ;

Berhane, Adugnaw ;

Beyene, Addisu Shunu ;

Bhutta, Zulfiqar A. ;

Biryukov, Stan ;

Boneya, Dube Jara ;

Brauer, Michael ;

Carpenter, David O. ;

Casey, Daniel ;

Christopher, Devasahayam Jesudas ;

Dandona, Lalit ;

Dandona, Rakhi ;

Dharmaratne, Samath D. ;

Huyen Phuc Do ;

Fischer, Florian ;

Geleto, Ayele ;

Ghoshal, Aloke Gopal ;

Gillum, Richard F. ;

Ginawi, Ibrahim Abdelmageem Mohamed ;

Gupta, Vipin ;

Hay, Simon I. ;

Hedayati, Mohammad T. ;

Horita, Nobuyuki ;

Hosgood, H. Dean ;

Jakovljevic, Mihajlo B. ;

James, Spencer Lewis .

LANCET RESPIRATORY MEDICINE, 2017, 5 (09) :691-706

← 1 2 →