A hierarchical scheme for cooperativity and folding in proteins

被引：21

作者：

Hansen, A

Jensen, MH

Sneppen, K

Zocchi, G

机构：

[1] Niels Bohr Inst, DK-2100 Copenhagen 0, Denmark

[2] NORDITA, DK-2100 Copenhagen, Denmark

来源：

PHYSICA A | 1998年 / 250卷 / 1-4期

关键词：

D O I：

10.1016/S0378-4371(97)00567-0

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

We propose a protein model based on a hierarchy of constraints that force the protein to follow certain pathways when changing conformation. The model exhibits a first-order phase transition, cooperativity and is exactly solvable. It also shows an unexpected symmetry between folding and unfolding pathways as suggested by a recent experiment. (C) 1998 Elsevier Science B.V. All rights reserved.

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页码：355 / 361

页数：7

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