Glucocorticoid regulation of diverse cognitive functions in normal and pathological emotional states

被引:309
作者
Erickson, K
Drevets, W
Schulkin, J
机构
[1] NIMH, DHHS, Mol Imaging Branch,Mood & Anxiety Disorders Progr, Sect Neuroimaging,NIH, Bethesda, MD 20814 USA
[2] Georgetown Univ, Sch Med, Dept Physiol & Biophys, Washington, DC 20007 USA
[3] NIMH, Clin Neuroendocrinol Branch, NIH, Bethesda, MD 20892 USA
关键词
glucocorticoids; emotion; cognition; amygdala; medial prefrontal; orbitofrontal; depression;
D O I
10.1016/S0149-7634(03)00033-2
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 [法学]; 0303 [社会学]; 030303 [人类学]; 04 [教育学]; 0402 [心理学];
摘要
The glucocorticoid hormone cortisol is essential for many forms of regulatory physiology and for cognitive appraisal. Cortisol, while associated with fear and stress response, is also the hormone of energy metabolism and it coordinates behavioral adaptation to the environmental and internal conditions through the regulation of many neurotransmitters and neural circuits. Cortisol has diverse effects on many neuropeptide and neurotransmitter systems thus affecting functional brain systems. As a result, cortisol affects numerous cognitive domains including attention, perception, memory, and emotional processing. When certain pathological emotional states are present, cortisol may have a role in differential activation of brain regions, particularly suppression of hippocampal activation, enhancement of amygdala activity, and dendritic reshaping in these regions as well as in the ventral prefrontal cortex. The coordinated actions of glucocorticoid regulation on various brain systems such as those implicated in emotional processing can lead to perceptual and cognitive adaptations and distortions of events that may be relevant for understanding mood disorders. (C) 2003 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:233 / 246
页数:14
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