Diversity of the human erythrocyte membrane, sialic acids in relation with blood groups

被引：60

作者：

Bulai, T

Bratosin, D

Pons, A

Montreuil, J

Zanetta, JP

机构：

[1] Univ Sci & Technol, CNRS, UMR 8576, Lab Glycobiol Struct & Fonctionnelle, F-59655 Villeneuve Dascq, France

[2] Natl Inst Biol Sci Res & Dev, Bucharest, Romania

来源：

FEBS LETTERS | 2003年 / 534卷 / 1-3期

关键词：

sialic acid; red blood cell; blood group; human erythrocyte;

D O I：

10.1016/S0014-5793(02)03838-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The composition of the human erythrocyte membrane (RBC) glycoprotein- and glycolipid-bound sialic acids of A, B, AB and O type donors was studied using a new method (Zanetta et al., Glycobiology 11 (2001) 663-676). In addition to Neu5Ac as the major compound, Kdn, Neu5,9Ac(2), Neu5,7Ac(2), Neu (de-N-acetylated-Neu5Ac), Neu5Ac8Me, Neu5Ac9Lt, Neu4,5Ac(2), Neu5,8Ac(2)9Lt and Neu5Ac8S were characterised. Among these different compounds, Neu5Ac8Me, Neu5Ac9Lt, Neu4,5Ac(2), Neu5,8Ac(2)9Lt and Neu5Ac8S have never been described and quantitatively determined before in human tissues or cells. Neu5Gc and its O-alkylated or O-acylated derivatives were not detected. (C) 2002 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.

引用

页码：185 / 189

页数：5

共 24 条

[1]

AMINOFF D, 1980, AM J HEMATOL, V9, P381

[2] Chemical diversity in the sialic acids and related α-keto acids:: An evolutionary perspective [J].