Peroxisome proliferator-activated receptors ligands and ischemia-reperfusion injury

被引：32

作者：

Di Paola, Rosanna

Cuzzocrea, Salvatore

机构：

[1] Univ Messina, Torre Biol Policlin, Sch Med, Dept Clin & Expt Med & Pharmacol, I-98100 Messina, Italy

[2] IRCCS, Ctr Neurol Bonino Pulejo, Messina, Italy

来源：

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY | 2007年 / 375卷 / 03期

关键词：

peroxisome proliferator-activated receptors; ischemia; reperfusion tissue injury;

D O I：

10.1007/s00210-007-0141-2

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

Peroxisome proliferator-activated receptors (PPARs) belong to a subfamily of transcription nuclear factors. Three isoforms of PPARs have been identified: alpha, beta/delta and gamma, encoded by different genes and distributed in various tissues. They play important roles in metabolic processes like regulation of glucose and lipid redistribution. They also have anti-atherogenic, anti-inflammatory as well as antihypertensive functions. There is good evidence that ligands of PPARs reduce tissue injury associated with ischemia and reperfusion. The potential utility of PPAR ligands in ischemia and reperfusion will be discussed in this review.

引用

页码：157 / 175

页数：19

共 189 条

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